期刊
PATHOLOGY
卷 55, 期 3, 页码 335-341出版社
ELSEVIER
DOI: 10.1016/j.pathol.2022.09.005
关键词
Idiopathic granulomatous mastitis; cystic neutrophilic granulo-matous mastitis; granuloma
类别
This study reviewed cases of IGM to assess histological parameters and clinical data. The cohort consisted of 79 cases, including 51 non-CNGM IGM and 28 CNGM. There were no significant differences in clinical or demographic data between the two groups, except for a younger age of presentation in CNGM. Most IGM cases resolved during the follow-up period, regardless of treatment. CNGM showed distinct histological features with more infiltrates of specific inflammatory cells.
Cases of IGM were reviewed for histological parameters including the presence of lipogranulomas and composition of inflammatory cells. Clinical data were obtained through hospital records. The cohort included 79 cases, including 51 non-CNGM IGM and 28 CNGM. Comparing non-CNGM IGM and CNGM, there were no differences in clinical or demo-graphical data, other than a younger age of presentation (36.2 vs 41.5 years, p=0.012) for CNGM. Most IGM resolved within the follow-up period (n=57/64, 89.1%), with similar outcomes regardless of treatment (p>0.05). In CNGM, there were more infiltrates of neutrophils (p=0.001), histiocytes (p=0.047), and multinucleated giant cells (p=0.006), but less lymphocytes (p=0.008). Coryne-bacteria was cultured in two (25%) cases of CNGM, and one non-CNGM IGM (14.3%). Gram-positive bacilli were identified in two cases of CNGM. ???Early??? lipogranulomas were observed closely associated to inflamed ducts in three cases of CNGM. Apart from age, there was no distinct clinical or microbio-logical feature for CNGM. These findings do not support CNGM as a distinct entity. Rather, CNGM-pattern may represent a continuum of IGM, possibly age-related and attributable to ductal inflammation and cystic changes in the breast
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