Design and execution of sham-controlled endoscopic trials in acute pancreatitis: Lessons learned from the SHARP trial

Article Gastroenterology & Hepatology

Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021

Anne F. Peery et al.

Summary: Gastrointestinal diseases in the United States result in significant healthcare utilization and expenditures, with millions of healthcare encounters and hundreds of thousands of deaths each year. To address this burden, focused clinical and public health efforts, along with increased research funding, are necessary.

GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

The Next EPISOD: Trends in Utilization of Endoscopic Sphincterotomy for Sphincter of Oddi Dysfunction from 2010-2019

Zachary L. Smith et al.

Summary: A sustained decrease in the utilization of endoscopic sphincterotomy for patients with Sphincter of Oddi Dysfunction (SOD) was observed, highlighting the importance of high-quality, multi-center, randomized controlled trials in driving evidence-based changes in clinical practice.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Clinical outcome of endoscopic therapy in patients with symptomatic pancreas divisum: a Dutch cohort study

David M. de Jong et al.

Summary: The study evaluated the success rates and long-term outcomes of endoscopic treatment in patients with symptomatic PDiv, showing moderate effectiveness with the highest yield in patients presenting with recurrent acute pancreatitis. Future studies are needed to assess factors predictive for success of endoscopic therapy and potential risk factors for relapse after ERCP.

ENDOSCOPY INTERNATIONAL OPEN (2021)

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Article Health Care Sciences & Services

A roadmap to using randomization in clinical trials

Vance W. Berger et al.

Summary: Restricted randomization procedures play a crucial role in clinical trials by promoting balance between treatment groups and enhancing the validity of statistical tests. This paper provides a systematic roadmap for selecting and applying these procedures, including exploration of statistical properties and considerations for when common model assumptions are violated. Randomization-based tests are highlighted as robust and valid alternatives to likelihood-based tests, with covariate-adjusted analysis recommended for ensuring validity of results, especially in cases with small sample sizes.

BMC MEDICAL RESEARCH METHODOLOGY (2021)

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Review Gastroenterology & Hepatology

Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis

Venkata S. Akshintala et al.

Summary: This study systematically compared the efficacy of NSAIDs, pancreatic stents, intravenous fluids, or a combination of these methods for preventing post-ERCP pancreatitis through network meta-analysis. Rectal diclofenac 100 mg was found to be the best performing rectal NSAID. Combinations of prophylaxis may be more effective, yet there is limited evidence.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology