Plasma renalase levels are associated with the development of acute pancreatitis

Article Multidisciplinary Sciences

Association of renalase with clinical outcomes in hospitalized patients with COVID-19

Basmah Safdar et al.

Summary: This retrospective cohort study investigated the relationship between blood renalase levels and disease severity and survival in COVID-19 patients. The results showed that patients with low renalase levels were more likely to experience hypoxia, require intensive care unit treatment, and undergo cardiopulmonary resuscitation. Every 1000 ng/ml increase in renalase levels decreased the risk of death or intubation and increased survival rate. Patients with high renalase and low interleukin-6 (IL-6) levels had the best survival.

PLOS ONE (2022)

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Article Multidisciplinary Sciences

Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma

Yasheen Gao et al.

Summary: Dysregulated renalase expression in PDAC tissues and its corresponding plasma levels are associated with advanced tumor characteristics, decreased overall survival, and reduced resectability in patients with locally advanced/borderline resectable PDAC.

PLOS ONE (2021)

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Review Cell Biology

Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

Thomas C. Pointer et al.

Summary: RNLS is a recently discovered protein with potent prosurvival and anti-inflammatory effects. Studies have shown its involvement in GI diseases and cancer, and future research should focus on its role in intestinal diseases and developing therapeutic agents.

CELLS (2021)

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Article Urology & Nephrology