Counterpoint: The value of benchmarking in observational studies of the longer term safety of antenatal corticosteroids

Article Public, Environmental & Occupational Health

Improving the external validity of Antenatal Late Preterm Steroids trial findings

Jennifer A. Hutcheon et al.

Summary: This study estimated the real-world absolute risk reduction and number-needed-to-treat (NNT) for antenatal corticosteroids at late preterm ages, taking into account the differences in gestational age between the trial participants and the real-world population. The results showed a lower absolute risk reduction and NNT in the real-world setting compared to the trial data, and also highlighted the differences in benefits between using corticosteroids at 34 weeks and 36 weeks.

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2023)

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Editorial Material Public, Environmental & Occupational Health

Point: Antenatal corticosteroid treatment in the late preterm period-Are the benefits worth the potential risks?

Eero Kajantie

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2023)

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Editorial Material Public, Environmental & Occupational Health

Point: Benchmarking can supplement transportability to answer critical questions about the effectiveness of antenatal corticosteroid administration

Ellen C. Caniglia et al.

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2023)

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Article Medicine, General & Internal

Antenatal corticosteroid administration and attention-deficit/hyperactivity disorder in childhood: a regression discontinuity study

Jennifer A. Hutcheon et al.

Summary: This study aimed to investigate the impact of fetal exposure to antenatal corticosteroids on the prescription rate of attention-deficit/hyperactivity disorder (ADHD) medication in childhood. By using a quasiexperimental design and analyzing the data, it was found that there was no significant correlation between fetal exposure to antenatal corticosteroids and the prescription rate of ADHD medication.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2022)

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Article Public, Environmental & Occupational Health

Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries

Hui Wang et al.

Summary: Maternal hypertensive disorders during pregnancy, especially pre-eclampsia, are associated with increased risks of ADHD, ASD, and ID in offspring. The timing and severity of pre-eclampsia play a significant role in these associations, with early-onset and severe cases showing the strongest links. These associations remain consistent across various subgroups and are independent of shared familial factors.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

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Article Medicine, General & Internal