4.5 Article

Stabilization of the Amorphous Structure of Spray-Dried Drug Nanoparticles

期刊

JOURNAL OF PHYSICAL CHEMISTRY B
卷 120, 期 34, 页码 9161-9165

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.6b05417

关键词

-

资金

  1. NSF [DMR-1310266]
  2. Harvard MRSEC [DMR-1420570]
  3. National Science Foundation under NSF [ECS-0335765]

向作者/读者索取更多资源

The bioavailability of hydrophobic drugs strongly increases if they are formulated as amorphous materials because the solubility of the amorphous phase is much higher than that of the crystal. Moreover, the stability of these particles against crystallization during storage increases with decreasing particle size. Hence, it is advantageous to formulate poorly water soluble drugs as amorphous nano particles. The formulation of an amorphous structure is often difficult because many of these drugs have a high propensity to crystallize. This difficulty can be overcome if drugs are spray dried using a microfluidic nebulator we recently developed. However, these nanoparticles agglomerate when they come in contact with each other, and this compromises the stability of their amorphous structure through crystallization. To improve their stability, we coat the nanoparticles with a sterically stabilizing polymer layer; this can be accomplished by co-spraying them with an excipient. However, this excipient must meet strict solubility limits, which severely limit the choice of polymers. Alternatively, the nanoparticles can be sterically stabilized by spraying them directly into a polymeric matrix; this enables a much wider choice of stabiliziting polymers.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据