Synthesis of (Hetero)aryl/Alkenyl Iodides via Ni-Catalyzed Finkelstein Reaction from Bromides or Chlorides

Aryl and alkenyl iodides are important intermediates for value-added targets in organic synthesis and common motifs in natural products and bioactive molecules. Thus, direct synthesis of aryl/alkenyl iodides from easily available and cost-effective materials under mild conditions is attractive. Herein, we reported a nickel-catalyzed Finkelstein reaction under mild conditions. Notably, a wide range of aryl/alkenyl bromides as well as chlorides could be transformed into corresponding iodides with broad functional group tolerance.

Automated summary

In this study, a nickel-catalyzed Finkelstein reaction under mild conditions was reported, which can convert a wide range of aryl/alkenyl bromides as well as chlorides into corresponding iodides with broad functional group tolerance.