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1,2-Diacylation of Alkynes Using Acyl Fluorides and Acylsilanes by P(III)/P(V) Catalysis

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03910

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We presented the phosphine-catalyzed 1,2-diacylation of alkynes using acyl fluorides and acylsilanes as acyl sources. The reaction relies on a formal oxidative addition-ligand metathesis-reductive elimination cycle based on phosphine redox catalysis, enabling the selective introduction of two different acyl groups into alkynes.
We report herein the phosphine-catalyzed 1,2-diacylation of alkynes using acyl fluorides and acylsilanes as acyl sources. The key to the success of the reaction is a formal oxidative addition-ligand metathesis-reductive elimination cycle based on phosphine redox catalysis, which allows for the installation of two different acyl groups into an alkyne in a regioselective manner.

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