Redox-Neutral 1,4-Dicarbonfunctionalization of 1,3-Butadiene by Merging Photoredox and Nickel

The diverse functionalization of 1,3-butadiene provides wide applicability toward the synthesis of abundant and useful allylic compounds. Here, we describe a three-component and redox-neutral assembly of readily available C=X compounds, 1,3-butadiene, and various nucleophiles by merging photoredox and nickel catalysis, enabling the rapid synthesis of structurally diverse homoallyl amines and homoallylic alcohols.

Automated summary

In this article, a three-component and redox-neutral synthesis of homoallyl amines and homoallylic alcohols is described. This reaction involves readily available C=X compounds, 1,3-butadiene, and various nucleophiles, and is catalyzed by the combination of photoredox and nickel catalysts.