期刊
ORGANIC LETTERS
卷 25, 期 3, 页码 477-482出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c04109
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This article describes an organocatalytic enantioselective formal hydro-arylation of 2-vinyl indoles for the synthesis of enantioenriched 2,3'-bis(indolyl)methanes bearing a quaternary carbon stereocenter. The reaction conditions are mild, the catalyst loading is low, and the efficiency and enantioselectivity are excellent. The resulting products exhibit promising anticancer activity.
An organocatalytic enantioselective formal hydro-arylation of 2-vinyl indoles for the preparation of enantioenriched 2,3 '-bis(indolyl)methanes bearing an all-carbon quaternary stereo -center is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained products showed promising anticancer activity.
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