One-Pot and Unsymmetrical Bis-Allylation of Malononitrile with Conjugated Dienes and Allylic Alcohols

A Pd/Ca catalytic system to promote the unsymmetrical bis-allylation of malononitrile was developed by selecting conjugated dienes and allylic alcohols as allylic reagents. This catalytic system suppressed the competitive symmetrical bisallylation process and guaranteed the desired unsymmetrical bisallylation with high chemoselectivity. A wide range of conjugated dienes and allylic alcohols were tolerated well in this transformation, and diverse 1,6-dienes were obtained with high efficiency.

Automated summary

A Pd/Ca catalytic system for the unsymmetrical bis-allylation of malononitrile was developed using conjugated dienes and allylic alcohols as allylic reagents. This system shows high chemoselectivity and efficiency, allowing the synthesis of diverse 1,6-dienes.