Selective Fluorosulfonylation of Thianthrenium Salts Enabled by Electrochemistry

A practical electrochemically driven method for fluorosul-fonylation of both aryl and alkyl thianthrenium salts has been disclosed. The strategy does not need external redox reagents or metal catalysts. In combination with C-H thianthrenation of aromatics, this method provides a new tool for the site-selective fluorosulfonylation of drugs.

Automated summary

A practical electrochemical method for fluorosulfonylation of aryl and alkyl thianthrenium salts without external redox reagents or metal catalysts is presented. This method, in combination with the C-H thianthrenation of aromatics, provides a new tool for site-selective fluorosulfonylation of drugs.