期刊
ORGANIC LETTERS
卷 24, 期 45, 页码 8381-8386出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03439
关键词
-
资金
- National Natural Science Foundation of China
- Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission)
- First-Class Discipline Construction and Characteristic Development Guidance Funds for the Central Universities
- [21871081]
- [22071054]
- [SLC13223002]
The synthesis of the longest polymannuronic acid of P. aeruginosa and the identification of the optimal antigen epitope for vaccine development were achieved through glycosylation reactions and screening with mouse serum antibodies.
Pseudomonas aeruginosa is a leading cause of urinary tract, pulmonary, and wound infections and is becoming increasingly resistant to antibiotics. Here, we report the iodonium-and gold(I)promoted bimodal glycosylation of glycosyl (Z)-ynenoates for highly fi-selective promoter-controlled synthesis and antigenic evaluation of a series of 1,2-cis-fi-linked mannuronic acid alginate glycans of P. aeruginosa up to a 24-mer, which represents the longest polymannuronic acid synthesized to date. By screening the six synthetic mannuronic acid alginate glycans with the mouse serum antibodies, we identified the mannuronic acid tetrasaccharide as the optimal antigen epitope for the development of vaccines against P. aeruginosa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据