期刊
ORGANIC LETTERS
卷 24, 期 51, 页码 9442-9446出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03842
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资金
- National Natural Science Foundation of China [21801180, 22101156]
- Natural Science Foundation of Shandong Province [ZR2018LB010, ZR2022QB083, ZR2021QB032]
- Academic promotion programme of Shandong First Medical University [2019QL008]
- Incubation Program of Youth Innovation of Shandong Province
Nitrogen-containing heterocycles play crucial roles in biologically active natural products and pharmaceuticals, and the palladium-catalyzed decarboxylative cycloaddition reactions are powerful synthetic tools. Vinyl benzoxazinones have emerged as versatile building blocks for nitrogenous skeletons.
Nitrogen-containing heterocycles are pivotal scaffolds in various biologically active natural products and pharmaceuticals and exhibit broad biological and medicinal activity.1 The strategies to access N-heterocyclic compounds have drawn great attention; among them, palladium-catalyzed decarboxylative cycloaddition reactions are powerful synthetic tool.2 Recently, vinyl benzoxazinones have emerged as versatile blocks for constructing nitrogenous skeletons.3,4 As shown in Scheme 1, in the presence of a palladium catalyst, vinyl benzoxazinone leads to a pi-allyl Pd-intermediate bearing a Nnucleophile, and the zwitterion could undergo four paths (a- d) to form N-heterocycles. Path a is well developed, and
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