期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 21, 期 4, 页码 775-782出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob02001g
关键词
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A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1-a]isoindoles is reported. The reaction shows good functional group compatibility and a broad substrate scope with up to 84% yields. Mechanistic studies suggest that the C-H cleavage may be the rate-determining step in this transformation.
A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C-H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5,1-a]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C-H cleavage might be the rate-determining step in this transformation.
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