期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 21, 期 5, 页码 910-924出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob02159e
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This article summarizes the routes to tetralones, tetralines, and naphthalenes based on the xanthate chemistry developed in the authors' laboratory. The reversible transfer of xanthates allows radical additions to unactivated alkenes and tolerates a wide range of functional groups, including common polar groups. Xanthates also enable radical ring closures onto aromatic rings, offering a convergent approach to building blocks relevant to pharmaceutical, agrochemical, and material sciences.
The present account summarises routes to tetralones, tetralines, and naphthalenes based on the chemistry of xanthates developed in the authors' laboratory. The degenerative reversible transfer of xanthates allows radical addition even to unactivated, electronically unbiased alkenes, and tolerates a broad range of functional groups, in particular common polar groups such as esters, ketones, nitriles, amides, carbamates, etc. Xanthates also allow radical ring closures onto aromatic rings. This feature, in combination with the intermolecular addition to alkenes, can be used to construct tetralones and tetralines. With the appropriate appendages, the former can be converted into napthalenes with a variety of substitution patterns. This translates into a convergent approach to a vast array of building blocks of interest to the pharmaceutical and agrochemical industries, and to material sciences.
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