期刊
CELL
卷 160, 期 3, 页码 447-460出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.01.002
关键词
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资金
- Crohn's and Colitis Foundation [R01 AI084887, R01 OD011170, 3132, 274415]
- Broad Medical Foundation [IBD-0357]
- NIH grant [5T32AI007163-35, 5T32CA009547, T32 HL007317-36, 5T32AI007172-34]
- European Union [305479]
- Leona M. and Harry B. Helmsley Charitable Trust
- NIHR Biomedical Research Centre awards
- University of Cambridge School of Clinical Medicine
- NIH Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research grant [U54 AI057160]
- NCI Cancer Center Support grant [P30 CA91842]
- National Center for Research Resources (NCRR) [UL1TR000448]
- NIHR Biomedical Research Centre award
- Agency for Healthcare Research and Quality [HS021747]
- [R01 AT007143]
- [DK071838]
- [AT001628]
- [DK062413]
- [DK046763-19]
- [AI067068]
- [U54DE023789-01]
- [U54 DE023798]
- [R01 DK092405]
Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
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