☆ 4.5 Review

MicroRNAs as early diagnostic biomarkers for non-small cell lung cancer (Review)

ONCOLOGY REPORTS (2023)

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Article Oncology

DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway

Bo Yang et al.

Summary: In this study, it was discovered that miR-152-3p suppresses proliferation in non-small cell lung cancer A549 cells by downregulating NCAM1. Additionally, DNMT3B negatively regulates the expression of miR-152-3p by modulating the methylation level in the miR-152-3p core region, thus mediating the proliferation of lung tumor cells.

ONCOLOGY LETTERS (2022)

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Article Oncology

MiR-205-5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer

Yu-Long Zhao et al.

Summary: miR-205-5p promotes cell proliferation and metastasis in lung cancer by negatively regulating the target gene TP53INP1, which further affects the expression of P21, RB1, and cyclin D1. Serum miR-205-5p is a valuable biomarker for lung cancer diagnosis.

THORACIC CANCER (2022)

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Article Oncology

MiR-224 promotes lymphatic metastasis by targeting ANGPTL1 in non-small-cell lung carcinoma

Haibo Han et al.

Summary: The study demonstrates that miR-224 plays a significant role in lymphatic metastasis of non-small-cell lung cancer and may serve as a potential biomarker for predicting lymphatic metastasis.

CANCER BIOMARKERS (2022)

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Article Medicine, Research & Experimental

Overexpression of the miR-143/145 and reduced expression of the let-7 and miR-126 for early lung cancer diagnosis

Lubomir Tulinsky et al.

Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Researchers have identified potential blood biomarkers (miRNA) for early diagnosis. This study found that the levels of many miRNAs were significantly altered in the blood of patients with early-stage lung cancer. The most important miRNA biomarkers for early detection of lung cancer are miR-143, let-7g, miR-126, let-7a, and miR-145. However, further validation is needed in larger cohorts for these individual miRNA biomarkers.

JOURNAL OF APPLIED BIOMEDICINE (2022)

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Article Oncology

Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8

Jinyou Li et al.

Summary: In this study, the researchers found that circDNER could suppress the progression of lung cancer by regulating the miR-139-5p/ITGB8 axis, suggesting that circDNER may serve as a potential prognostic biomarker and therapeutic target for lung cancer treatment.

THORACIC CANCER (2022)

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Article Biophysics

Exosomal microRNAs array sensor with a bioconjugate composed of p53 protein and hydrazine for the specific lung cancer detection

Rabbee G. Mahmudunnabi et al.

Summary: This study demonstrates a novel strategy for the early diagnosis of lung cancer by detecting microRNAs encapsulated in exosomes using immunomagnetic isolation. The researchers selectively extracted exo-miRNAs from patient serum by capturing miRNA from lysed exosomes with specially designed capture probe modified magnetic beads. The sensor probe formed through T4 DNA polymerase-mediated in situ formation of chimeric 5'-miRNA-DNA-3' (Target) and p53 protein recognition showed excellent analytical performance, with a dynamic range between 100 aM and 10 pM and a detection limit of 92 (+/- 0.1) aM. Furthermore, a multiplexed array sensor was prepared to detect four exo-miRNAs at femtomolar levels in cell culture media and lung cancer patient serum samples.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Immunology

LncRNA-CCAT1/miR-152-3p is involved in CSE-induced inflammation in HBE cells via regulating ERK signaling pathway

Dandan Zong et al.

Summary: This study demonstrates that dysregulated long non-coding RNA (lncRNA) CCAT1 plays a significant role in cigarette smoke induced inflammation in chronic obstructive pulmonary disease (COPD). CCAT1 is highly expressed in the lung tissues of smokers with COPD compared to never-smokers without COPD. It directly targets miR-152-3p and positively regulates the ERK signaling pathway, leading to inflammation in human bronchial epithelial cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Oncology

Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050

Sophie Pilleron et al.

Summary: This study utilized GLOBOCAN estimates to describe the cancer incidence among adults aged 80 years or older globally and regionally in 2018, projecting the trends to 2050. The most common cancer sites for this age group globally were breast, lung, and colon for females, and prostate, lung, and colon for males. It is estimated that by 2050, there will be a significant increase in new cancer cases among adults aged 80 years or older worldwide, posing challenges to healthcare systems and emphasizing the need for tailored cancer control policies for the elderly population.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway

Jinjin Duan et al.

Summary: The study found that TNS1 is upregulated in NSCLC cells and tissues, and is associated with the prognosis of NSCLC patients. Additionally, TNS1 promotes the growth and metastasis of NSCLC cells via the Akt/mTOR/RhoA pathway. miR-152 targets TNS1 to influence the progression of NSCLC.

BIOSCIENCE REPORTS (2021)

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Article Oncology

miR-654-3p suppresses cell viability and promotes apoptosis by targeting RASAL2 in non-small-cell lung cancer

Jie Xiong et al.

Summary: This study indicates that miR-654-3p can suppress cell viability and induce apoptosis in non-small-cell lung cancer cells by targeting RASAL2. These findings contribute to the development of treatments for NSCLC.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

miR-139-5p enhances cisplatin sensitivity in non-small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox-B2

Hailian Du et al.

Summary: This study revealed that the lower expression of miR-139-5p in non-small cell lung cancer (NSCLC) tissues can increase cell apoptosis and inhibit proliferation via modulating the PI3K/AKT/caspase-3 signaling pathway, thereby enhancing sensitivity to cisplatin (DDP). Targeting HOXB2 through miR-139-5p could serve as a novel approach to reverse DDP resistance and improve chemosensitivity in NSCLC treatment.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

MiR-196b Promotes the Invasion and Migration of Lung Adenocarcinoma Cells by Targeting AQP4

Xuhui Wu et al.

Summary: The study demonstrated that miR-196b promotes invasion and migration of LUAD cells by down-regulating AQP4, while overexpression of AQP4 can suppress the promotive effect of miR-196b on cancer cell invasion and migration.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

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Article Oncology

Plasma miR-1247-5p, miR-301b-3p and miR-105-5p as potential biomarkers for early diagnosis of non-small cell lung cancer

Xiaohan Dong et al.

Summary: The study indicates that high expression of miR-1247-5p, miR-301b-3p, and miR-105-5p can accelerate the tumorigenesis of NSCLC, and these three miRNAs in plasma serve as novel biomarkers for early diagnosis of NSCLC patients.

THORACIC CANCER (2021)

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Review Pharmacology & Pharmacy

The biology, function, and applications of exosomes in cancer

Jinyi Liu et al.

Summary: Exosomes are cell-derived nanovesicles that play essential roles in intercellular communication, cancer progression, and drug delivery. They have potential applications in cancer diagnosis, treatment, and research.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Cell Biology

Tensins - emerging insights into their domain functions, biological roles and disease relevance

Yi-Chun Liao et al.

Summary: Tensins are a family of focal adhesion proteins consisting of four members in mammals, playing important roles in the molecular linkage between the extracellular matrix and cytoskeletal networks, mediating signal transduction pathways, and regulating various physiological processes in cells. They are essential for maintaining normal tissue structures and functions, especially in the kidney and heart, as well as in muscle regeneration in animals. This review discusses the domain functions and biological roles of tensins in cells and mice, emphasizing their relevance to human diseases.

JOURNAL OF CELL SCIENCE (2021)

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Article Cell Biology

Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10

Cheng Yuan et al.

Summary: miR-195-5p inhibits cell proliferation, invasion, and migration, induces G1 phase arrest and apoptosis, and enhances radiosensitivity in lung adenocarcinoma cells by targeting HOXA10, suggesting its potential as a candidate for LUAD treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Multidisciplinary Sciences

Diagnostic value of PPARδ and miRNA-17 expression levels in patients with non-small cell lung cancer

Monika Migdalska-Sek et al.

Summary: The study found that the expressions of PPAR delta and miR-17 were significantly lower in NSCLC patients compared to the control group, showing potential diagnostic value in distinguishing NSCLC from controls. Additionally, differences in expression were observed in different subgroups, indicating potential roles in early diagnosis and differentiation of NSCLC histotypes.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis

Juan Zhang et al.

Aging-US (2021)

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Review Biochemistry & Molecular Biology

MicroRNAs in Metastasis and the Tumour Microenvironment

Carla Sole et al.

Summary: Metastasis, the spread of cancer cells from the primary tumor to other parts of the body, is a primary cause of cancer-related mortality. Understanding the role of microRNAs in cancer development and progression, particularly in the interaction between tumor cells and the tumor microenvironment, is crucial for developing new strategies to combat metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

MicroRNA 144 inhibits cell migration and invasion and regulates inflammatory cytokine secretion through targeting toll like receptor 2 in non-small cell lung cancer

Rong Pu et al.

Summary: Our study revealed that miR-144 was downregulated in NSCLC tissues and cell lines, while TLR2 protein expression was significantly higher compared to normal lung tissues. miR-144 inhibited migration, invasion, and secretion of IL-1 beta, IL-6, and IL-8 in A549 cells by downregulating TLR2 expression.

ARCHIVES OF MEDICAL SCIENCE (2021)

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Article Pharmacology & Pharmacy

LncRNA PCGsEM1 Contributes to the Proliferation, Migration and Invasion of Non-small Cell Lung Cancer Cells via acting as a Sponge for miR-152-3p

Jianhui Huang et al.

Summary: In this study, increased expression of PCGEM1 was observed in NSCLC tissues and cells, and its knockdown inhibited NSCLC cell proliferation, migration, and invasion. MiR-152-3p was identified as a target gene of PCGEM1, mediating its effects on NSCLC cell behaviors. The PCGEM1/miR-152-3p axis may offer new therapeutic targets for NSCLC treatment.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Review Biochemistry & Molecular Biology

FGF/FGFR signaling: From lung development to respiratory diseases

Lehe Yang et al.

Summary: The FGF/FGFR signaling system is crucial in regulating lung development and respiratory diseases by controlling cell proliferation, differentiation, migration, survival, and metabolism. This signaling pathway plays a key role in various biological processes such as embryogenesis, angiogenesis, wound repair, tissue homeostasis, and cancer, highlighting its significance in lung health and disease.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

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Article Medicine, General & Internal

SIRT3 acts as a novel biomarker for the diagnosis of lung cancer A retrospective study

Feng Tao et al.

Summary: SIRT3 expression is significantly down-regulated in lung cancer tissues and serum samples, and may serve as a promising biomarker for early diagnosis of lung cancer.

MEDICINE (2021)

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Article Cell Biology

Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer

Zijian Ma et al.

Summary: miR-3157-3p transferred via exosomes from NSCLC cells to vascular endothelial cells is involved in the formation of pre-metastatic niche before tumor metastasis, and may serve as a blood-based biomarker for NSCLC metastasis. Exosome miR-3157-3p regulates VEGF/MMP2/MMP9 and occludin expression in endothelial cells by targeting TIMP/KLF2, promoting angiogenesis and increasing vascular permeability, as well as enhancing NSCLC metastasis in vivo.

CELL DEATH & DISEASE (2021)

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Article Oncology

Four plasma miRNAs act as biomarkers for diagnosis and prognosis of non-small cell lung cancer

He-Guo Jiang et al.

Summary: This study investigated the diagnostic and prognostic value of four plasma miRNAs in non-small cell lung cancer (NSCLC), confirming that miR-210, miR-1290, miR-150, and miR-21-5p were highly expressed in NSCLC patients. The four-miRNA panel showed high accuracy in distinguishing NSCLC patients from healthy controls and those with benign lung disease, suggesting their potential as useful biomarkers for early diagnosis and prognosis of NSCLC.

ONCOLOGY LETTERS (2021)

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Article Oncology

TEP linc-GTF2H2-1, RP3-466P17.2, and lnc-ST8SIA4-12 as novel biomarkers for lung cancer diagnosis and progression prediction

Xinyi Li et al.

Summary: The study found that TEP linc-GTF2H2-1 and RP3-466P17.2 were significantly downregulated, while lnc-ST8SIA4-12 was significantly upregulated in patients with lung cancer, showing higher AUC values. The combination of these lncRNAs demonstrated significantly improved diagnostic efficiencies for lung cancer and early-stage lung cancer, with AUC values of 0.921 and 0.895, respectively.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis

Hironori Matsuyama et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

MicroRNA-based biomarkers for diagnosis of non-small cell lung cancer (NSCLC)

Jipei Liao et al.

THORACIC CANCER (2020)

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Article Cell & Tissue Engineering

MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1

Guoli Zhao et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Medicine, Research & Experimental

Evaluation of Exosomal miRNA in Blood as a Potential Diagnostic Biomarker for Human Non-Small Cell Lung Cancer

Zhenan Xu et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Biochemistry & Molecular Biology

Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci

Renfu Shang et al.

MOLECULAR CELL (2020)

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MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1

Dawei Wang et al.

MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

MiR-139-5p/SLC7A11 inhibits the proliferation, invasion and metastasis of pancreatic carcinoma via PI3K/Akt signaling pathway

Jin-Hui Zhu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways

Patricia P. Reis et al.

CANCERS (2020)

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A novel circulating miRNA-based signature for the early diagnosis and prognosis prediction of non-small-cell lung cancer

Chengwei Zhou et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Circulating miR-92b and miR-375 for monitoring the chemoresistance and prognosis of small cell lung cancer

Ming Li et al.

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

Genetic and Clinical Characterization of HOXB2 in Glioma

Xin Pan et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

Tumor-Derived Exosomal miRNAs as Diagnostic Biomarkers in Non-Small Cell Lung Cancer

Zhijun Zhang et al.

FRONTIERS IN ONCOLOGY (2020)

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Identification of Circulating miR-762 as a Novel Diagnostic and Prognostic Biomarker for Non-Small Cell Lung Cancer

Lei Chen et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

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MicroRNA-629 promotes the tumorigenesis of non-small-cell lung cancer by targeting FOXO1 and activating PI3K/AKT pathway

Lin Zhu et al.

CANCER BIOMARKERS (2020)

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Article Oncology

Serum exosomal miR-1269a serves as a diagnostic marker and plays an oncogenic role in non-small cell lung cancer

Xue Wang et al.

THORACIC CANCER (2020)

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Clinical Value of Serum and Exhaled Breath Condensate miR-186 and IL-1β Levels in Non-Small Cell Lung Cancer

Haiqin Xie et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

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Serum miR-339-3p as a potential diagnostic marker for non-small cell lung cancer

Keson Trakunram et al.

CANCER BIOLOGY & MEDICINE (2020)

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PM2.5 downregulates MicroRNA-139-5p and induces EMT in Bronchiolar Epithelium Cells by targeting Notch1

Yunxia Wang et al.

JOURNAL OF CANCER (2020)

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Boxue He et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Mohammad Askandar Iqbal et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

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miR-224-5p inhibits proliferation, migration, and invasion by targeting PIK3R3/AKT3 in uveal melanoma

Jianchang Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis

Matteo Fassan et al.

TRANSLATIONAL ONCOLOGY (2019)

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Detection of circulating exosomal miR-17-5p serves as a novel non-invasive diagnostic marker for non-small cell lung cancer patients

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miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer

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IN VIVO (2019)

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Serum microRNA Signature Is Capable of Early Diagnosis for Non-Small Cell Lung Cancer

Xia Yang et al.

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Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy

Lais Osmani et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Tumor-Targeting Anti-MicroRNA-155 Delivery Based on Biodegradable Poly(ester amine) and Hyaluronic Acid Shielding for Lung Cancer Therapy

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CHEMPHYSCHEM (2018)

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Shaohua Lu et al.

LUNG CANCER (2018)

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Rie Kanaoka et al.

ONCOLOGY (2018)

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Won-Il Choi et al.

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Zhenqiang Sun et al.

MOLECULAR CANCER (2018)

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Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer

Qingyun Liu et al.

ONCOTARGET (2017)

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α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer

Panpan Zhan et al.

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Derek de Rie et al.

NATURE BIOTECHNOLOGY (2017)

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Article Oncology

Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer

Hitoshi Dejima et al.

ONCOLOGY LETTERS (2017)

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Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression

Franco Grimolizzi et al.

SCIENTIFIC REPORTS (2017)

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Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis

Asawari Korde et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non-Small Cell Lung Cancer Using Next-Generation Sequencing

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CLINICAL CANCER RESEARCH (2017)

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Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study

Wanbo Liu et al.

PEDIATRIC SURGERY INTERNATIONAL (2016)

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Evan C. Naylor

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2016)

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miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2

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Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

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MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2

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