4.8 Article

Intracellular angiopoietin-1 promotes TKI-resistance via activation of JAK/STAT5 pathway in chronic myeloid leukemia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia

Haidee Aranda-Tavio et al.

Summary: JKST6 exhibits potent antitumoral activity against CML cells by modulating apoptosis signaling pathways and mitosis control, inhibiting cell proliferation. Additionally, it shows effectiveness in BCR-ABL1-positive and resistant cells, suggesting its potential as a novel multikinase modulator in CML therapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Cell Biology

Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future

Valentina R. Minciacchi et al.

Summary: The article chronicles the journey of chronic myeloid leukemia, focusing on molecular pathways and treatment strategies aimed at eradicating leukemia stem cells.
Article Cell Biology

PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia

Dan Ma et al.

Summary: The study found that overexpression of PKC-beta is significantly correlated with TKI resistance in CML, with Alox5 and its related pathway playing a key role in this process by activating the ERK1/2 pathway. Inhibition of PKC-beta overexpression could potentially be a novel therapeutic mechanism to overcome TKI resistance in CML.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Oncology

Response and Resistance to BCR-ABL1-Targeted Therapies

Theodore P. Braun et al.

CANCER CELL (2020)

Article Gastroenterology & Hepatology

Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma

Michael Teufel et al.

GASTROENTEROLOGY (2019)

Review Oncology

STAT5 and STAT5 Inhibitors in Hematological Malignancies

Manlio Tolomeo et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Mechanisms of Disease Progression and Resistance to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia: An Update

Luana Bavaro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Direct Targeting Options for STAT3 and STAT5 in Cancer

Anna Orlova et al.

CANCERS (2019)

Article Oncology

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition

Rebecca Mitchell et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Oncology

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition

Rebecca Mitchell et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Article Medicine, General & Internal

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia

Andreas Hochhaus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Hematology

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

Elif Birtas Atesoglu et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2016)

Article Hematology

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

Elif Birtas Atesoglu et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2016)

Article Biochemistry & Molecular Biology

Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer

Sophia Pinz et al.

BMC MOLECULAR BIOLOGY (2016)

Editorial Material Cell Biology

Targeting Tie2 and the host vascular response in sepsis

Samir M. Parikh

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Oncology

Src family kinases and their role in hematological malignancies

Matthew Ku et al.

LEUKEMIA & LYMPHOMA (2015)

Article Cell & Tissue Engineering

Kinase-Independent Mechanisms of Resistance of Leukemia Stem Cells to Tyrosine Kinase Inhibitors

Christine Victoria Ichim

STEM CELLS TRANSLATIONAL MEDICINE (2014)

Editorial Material Cell Biology

Adding a new facet to STAT5 in CML Multitasking for leukemic cells

Wolfgang Warsch et al.

CELL CYCLE (2013)

Article Medicine, General & Internal

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome-Positive Leukemias

J. E. Cortes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Oncology

Targeting the ANGPT-TIE2 pathway in malignancy

Hanhua Huang et al.

NATURE REVIEWS CANCER (2010)

Article Biochemistry & Molecular Biology

Discovery of chromone-based inhibitors of the transcription factor STAT5

Judith Mueller et al.

CHEMBIOCHEM (2008)

Article Gastroenterology & Hepatology

Angiopoietin-1 targeted RNA interference suppresses angiogenesis and tumor growth of esophageal cancer

Xiao-Hong Liu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Dermatology

STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through SRC and JAK1 kinases

Alireza Mirmohammadsadegh et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)

Article Gastroenterology & Hepatology

Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma

T Torimura et al.

JOURNAL OF HEPATOLOGY (2004)