期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 33, 期 3, 页码 671-681出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2022.11.026
关键词
Palmitic acid; Female rats; Lycopene; Inflammation; Histopathology; Heart failure
This study evaluated the impact of lycopene (LYC) against palmitate (PA)-invoked cardiotoxicity. The results showed that LYC possesses anti-lipidemic, antioxidant, cytoprotective, and anti-inflammatory effects, and can reverse the cardiotoxicity caused by PA and improve tissue damage.
Background and aims: Obesity-related heart failure is exacerbated by excessive intake of saturated fats such as palmitate (PA). Lycopene (LYC) possesses anti-lipidemic, antioxidant, cy-toprotective, and anti-inflammatory effects. This study, therefore, evaluated the impact of LYC against PA-invoked cardiotoxicity.Methods and results: Thirty-six female rats were equally divided into six groups: control; PA (5 mM); PA thorn LYC (24 mg/kg); PA thorn LYC (48 mg/kg); LYC (24 mg/kg); and LYC (48 mg/kg). The PA was administered five times weekly for seven weeks, while the LYC was given for the last two weeks. Lipids in the blood and the heart were estimated, as were oxidative stress and anti-oxidant indices, cardiac function, inflammation, and histology. Palmitate overload occasioned a significant (p < 0.05) increase in cardiac cholesterol (50% ), phospholipids (19 %), and non-esterified fatty acids (40%). However, triglyceride levels decreased (38%). Furthermore, malon-dialdehyde (45%), hydrogen peroxide (33%) levels and myeloperoxidase activity increased (79%). Also, cardiac gamma-glutamyl transferase (50%), serum creatine kinase activities (1.34 folds), NF-kB, interleukin1b, and interleukin-6 mRNA expression increased in the PA group rela-tive to the control. In contrast, reduced glutathione (13%) and nitric oxide levels (22 %), interleukin-10 mRNA expression, cardiac creatine kinase (35%), lactate dehydrogenase (33%), aspartate, and alanine transaminase activities decreased markedly (15-and 10%, respectively). Also, PA caused hyperemia, congestion of the cardiac interstitium, and infiltration of inflamma-tory cells. However, treatment with LYC reversed the features of cardiotoxicity and histological complications caused by PA. These observations are likely because LYC has anti-inflammatory, antioxidant, and cytoprotective properties.Conclusion: Thus, LYC might be an appropriate remedy to manage PA-induced cardiotoxicity in female rats.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
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