期刊
NUCLEIC ACIDS RESEARCH
卷 51, 期 D1, 页码 D1117-D1121出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkac982
关键词
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PICKLES is an updated web interface for accessing a database of genome-scale CRISPR knockout fitness screens in human cell lines. It allows researchers to explore gene knockout fitness phenotypes across different cell lines and tissue types, and compare them with fitness, expression, or mutation profiles of other genes.
PICKLES (https:// pickles.hart-lab.org) is an updated web interface to a freely available database of genome-scale CRISPR knockout fitness screens in human cell lines. Using a completely rewritten interface, researchers can explore gene knockout fitness phenotypes across cell lines and tissue types and compare fitness profiles with fitness, expression, or mutation profiles of other genes. The database has been updated to include data from three CRISPR libraries (Avana, Score, and TKOv3), and includes information from 1162 whole-genome screens probing the knockout fitness phenotype of 18 959 genes. Source code for the interface and the integrated database are available for download.
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