4.7 Article

Dynamical analysis of astrocyte-induced neuronal hyper-excitation

期刊

NONLINEAR DYNAMICS
卷 111, 期 8, 页码 7713-7728

出版社

SPRINGER
DOI: 10.1007/s11071-022-08202-y

关键词

Astrocyte; Neuron; Bifurcation; Hyper-excitation

向作者/读者索取更多资源

This paper presents a computational model that explores integrated information in the bidirectional communication between neurons and astrocytes. The study analyzes the dynamics and information transfer process when stimulating metabotropic glutamate in coupled neuron and astrocyte models. The results demonstrate that the stimulation and coupling strength induce neuronal hyperexcitation, which is partially connected to epileptic instabilities. Additionally, the sustained firing activities of neurons can persist after stimulation cessation due to the time it takes for calcium concentration in astrocytes to reach a steady state. Furthermore, reducing astrocyte feedback effectively inhibits seizure-like firing in neurons from the perspective of neuronal energy consumption.
This paper introduces a computational model of integrated information in bidirectional neuron-astrocyte communication. Dynamical analysis and information transfer process are studied when stimulation of metabotropic glutamate is loaded into neuron and astrocyte in coupled model, respectively. The results show that the loading glutamate stimulus and coupling strength cause neuronal hyper-excitation, which is in some way linked to the epileptic instabilities. A period of sustained neuronal firing activities could continue after cessation of stimulation because of how long it takes for calcium concentration in astrocyte to decrease to steady state. Additionally, we also found that reducing the feedback of astrocyte could effectively inhibit neuronal seizure-like firing from the aspect of neuronal energy consumption in somatic firing.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据