期刊
CELL
卷 160, 期 4, 页码 673-685出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.01.008
关键词
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资金
- Agence Nationale de la Recherche (ANR) [ANR-09-PIRI-0027]
- Human Frontiers in Science Program
- Austrian Science Foundation (FWF) [T560-B17, I 812-B12]
- Agence Nationale de la Recherche (ANR) [ANR-09-PIRI-0027] Funding Source: Agence Nationale de la Recherche (ANR)
- Austrian Science Fund (FWF) [I 812, T 560] Funding Source: researchfish
- Austrian Science Fund (FWF) [T560] Funding Source: Austrian Science Fund (FWF)
3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell migration mode in early zebrafish embryos, termed stable-bleb migration. Stable-bleb cells display an invariant polarized balloon-like shape with exceptional migration speed and persistence. Progenitor cells can be reversibly transformed into stable-bleb cells irrespective of their primary fate and motile characteristics by increasing myosin II activity through biochemical or mechanical stimuli. Using a combination of theory and experiments, we show that, in stable-bleb cells, cortical contractility fluctuations trigger a stochastic switch into amoeboid motility, and a positive feedback between cortical flows and gradients in contractility maintains stable-bleb cell polarization. We further show that rearward cortical flows drive stable-bleb cell migration in various adhesive and non-adhesive environments, unraveling a highly versatile amoeboid migration phenotype.
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