期刊
NEW PHYTOLOGIST
卷 237, 期 6, 页码 2224-2237出版社
WILEY
DOI: 10.1111/nph.18702
关键词
AaMYB108; Artemisia annua; artemisinin biosynthesis; jasmonic acid; light signal; transcription factor
In this study, a transcription factor named AaMYB108 was identified as a positive regulator of artemisinin biosynthesis in A. annua. AaMYB108 promotes artemisinin biosynthesis by interacting with a previously characterized positive regulator, AaGSW1. Additionally, AaMYB108 interacts with AaCOP1 and AaJAZ8, and its function is influenced by these proteins. Through experiments with transgenic plants, it was found that the promotion of artemisinin by light and JA depends on the presence of AaMYB108. Overall, this study reveals the molecular mechanism of JA regulating artemisinin biosynthesis depending on light and provides new insights into the integration of light and phytohormone signaling in plants.
Artemisinin, a sesquiterpene compound synthesized and stored in the glandular trichome of Artemisia annua leaves, has been used to treat malaria. Previous studies have shown that both light and jasmonic acid (JA) can promote the biosynthesis of artemisinin, and the promotion of artemisinin by JA is dependent on light. However, the specific molecular mechanism remains unclear.Here, we report a MYB transcription factor, AaMYB108, identified from transcriptome analysis of light and JA treatment, as a positive regulator of artemisinin biosynthesis in A. annua. AaMYB108 promotes artemisinin biosynthesis by interacting with a previously characterized positive regulator of artemisinin, AaGSW1.Then, we found that AaMYB108 interacted with AaCOP1 and AaJAZ8, respectively. The function of AaMYB108 was influenced by AaCOP1 and AaJAZ8. Through the treatment of AaMYB108 transgenic plants with light and JA, it was found that the promotion of artemisinin by light and JA depends on the presence of AaMYB108.Taken together, our results reveal the molecular mechanism of JA regulating artemisinin biosynthesis depending on light in A. annua. This study provides new insights into the integration of light and phytohormone signaling to regulate terpene biosynthesis in plants.
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