期刊
CELL
卷 163, 期 3, 页码 684-697出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.09.036
关键词
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资金
- NSF [MCB 1158181, 0519869, MCB 0923727, IOS 1444561]
- NCSU-RISF
- Marie Curie COFUND U-Mobility postdoctoral fellowship
- University of Malaga
- EU [246550]
- Ministerio de Educacion
- NSF-REU [MCB 06103224]
- NCBI SRA [SRP056795]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1444561] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1254423] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1158181, 0519869] Funding Source: National Science Foundation
The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only recently become technically feasible. Using the well-characterized signaling pathway of the phytohormone ethylene and plant-optimized genome-wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene-specific translational control mechanism. Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Furthermore, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper activation of ethylene responses. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator.
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