Catalytic synthesis of seven-membered carbocycles via ring expansion of cyclic β-ketoesters

A catalytic method affording seven-membered carbon rings via two-carbon expansion of five-membered beta-ketoesters has been developed. This method tolerates various alkynyl 1,2-diketones, common ynones, and alkynyl ketoesters, and affords the corresponding products with multiple functional groups under mild and environmentally benign conditions.

Automated summary

A catalytic method has been developed for the two-carbon expansion of five-membered beta-ketoesters to afford seven-membered carbon rings, tolerating various alkynyl 1,2-diketones, common ynones, and alkynyl ketoesters to generate products with multiple functional groups under mild and environmentally benign conditions.