Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson's Disease: A Novel and Futuristic Approach

Parkinson's disease is a neurodegenerative disorder which is characterised mostly by loss of dopaminergic nerve cells throughout the nigral area mainly as a consequence of oxidative stress. Muscle stiffness, disorganised bodily responses, disturbed sleep, weariness, amnesia, and voice impairment are all symptoms of dopaminergic neuron degeneration and existing symptomatic treatments are important to arrest additional neuronal death. Some cannabinoids have recently been demonstrated as robust antioxidants that might protect the nerve cells from degeneration even when cannabinoid receptors are not triggered. Cannabinoids are likely to have property to slow or presumably cease the steady deterioration of the brain's dopaminergic systems, a condition for which there is now no treatment. The use of cannabinoids in combination with currently available drugs has the potential to introduce a radically new paradigm for treatment of Parkinson's disease, making it immensely useful in the treatment of such a debilitating illness.

Automated summary

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopaminergic nerve cells due to oxidative stress. Symptoms include muscle stiffness, disturbed sleep, fatigue, and voice impairment. Recent studies have shown that certain cannabinoids act as antioxidants and may protect nerve cells from degeneration. Combining cannabinoids with existing drugs could potentially revolutionize the treatment of Parkinson's disease, offering new hope for patients suffering from this debilitating illness.