期刊
NEUROSCIENCE RESEARCH
卷 189, 期 -, 页码 29-36出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2022.12.021
关键词
Synaptic plasticity; Online and offline synaptic plasticity; Long-term potentiation; Structural plasticity; Systems memory consolidation; Hippocampus; Anterior cingulate cortex
Memories are consolidated in the brain during sleep, with neuronal activity patterns being replayed in the hippocampus. This replay triggers changes in synaptic transmission, influencing long-term memory. Sleep induces offline synaptic plasticity, involving both potentiation and depression of synaptic transmission, which is different from online synaptic plasticity occurring immediately after a memory event.
After initial formation during learning, memories are further processed in the brain during subsequent days for long-term consolidation, with sleep playing a key role in this process. Studies have shown that neuronal activity patterns during the awake period are repeated in the hippocampus during sleep, which may coordinate brain-wide reactivation leading to memory consolidation. Consistently, perturbation of this activity blocks the for-mation of long-term memory. This 'replay' of activity during sleep likely triggers plastic changes in synaptic transmission, a cellular substrate of memory, in multiple brain regions, which likely plays a critical role in long-term memory. Two forms of synaptic plasticity, potentiation and depression of synaptic transmission, are induced in parallel during sleep and is termed offline synaptic plasticity, as opposed to the online synaptic plasticity that occurs immediately following a memory event.
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