期刊
NEUROSCIENCE RESEARCH
卷 188, 期 -, 页码 28-38出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2022.11.004
关键词
Glial fibrillary acidic protein; Nestin; NG2 cells; PDGFR ?; Oligodendrocyte
We identified a novel group of cells in the dorsal section of the aqueduct of Sylvius, called dorsal aqueduct niche or DAN, which express glial/stem cell markers and have the potential to generate new cells. These cells resemble tanycytes of the third ventricle and may act as a niche for glial cell generation in the adult mouse brain.
The aqueduct of Sylvius connects the third with the fourth ventricle and is surrounded by the Periaqueductal Grey. Here, we report a novel niche of cells in the dorsal section of the aqueduct, hereby named dorsal aqueduct niche or DAN, by applying a battery of selective markers and transgenic mouse lines. The somata of DAN cells are located toward the lumen of the ventricle forming multiple layers in close association with the cerebrospinal fluid (CSF). A single process emerges from the soma and run with the blood vessels. Cells of the DAN express radial glia/stem cell markers such as GFAP, vimentin and nestin, and the glutamate transporter GLAST or the oligodendrocyte precursor/pericyte marker NG2, thereby suggesting their potential for the generation of new cells. Morphologically, DAN cells resemble tanycytes of the third ventricle, which transfer biochemical signals from the CSF to the central nervous system and display proliferative capacity. The aqueduct ependymal lining can proliferate as observed by the integration of BrdU and expression of Ki67. Thus, the dorsal section of the aqueduct of Sylvius possesses cells that may act a niche of new glial cells in the adult mouse brain.
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