The intergenerational effects of parental physical activity on offspring brain and neurocognition in humans: A scoping review

Animal models suggest physical activity (PA) has intergenerational effects on brain health and neurocognition. This scoping review compiles the human literature in this area, identifies knowledge gaps, and makes recom-mendations for future research. We systematically searched for experimental or observational studies conducted in humans, published in English, and reporting parental PA exposure (preconception or prenatal) and subsequent offspring brain and neurocognition. Two reviewers independently screened studies according to predetermined inclusion criteria. Fourteen studies were included (four experimental and 10 observational) reporting on 93,486 parent-child dyads (100% maternal, 0% paternal). Prenatal maternal PA exposure was examined in 10 (71%) studies, while preconception and prenatal PA exposure was examined in four (29%) studies. Maternal PA exposure was positively related to offspring (0-20y) brain and neurocognitive development in 25% of experi-mental studies and 100% of observational studies. Little is known about the intergenerational effects of parental PA on offspring brain and neurocognition in humans, particularly paternal preconception PA. More experimental studies with longer offspring follow-up and more objective and/or mechanistic assessments are required.

Automated summary

Animal models suggest that physical activity has intergenerational effects on brain health and neurocognition. This scoping review examines the human literature in this area and finds limited understanding of the intergenerational effects of parental physical activity on offspring brain and neurocognition, especially regarding paternal preconception physical activity. More experimental studies with longer offspring follow-up and more objective and mechanistic assessments are needed.