☆ 4.7 Article

Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2023)

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Summary: The study demonstrated that fucoxanthin may be a promising compound for improving cognitive functions through antioxidant, anti-inflammatory, and neuroprotective mechanisms, as well as inhibition of acetylcholinesterase (AChE) enzyme activities, A beta((1-42)) accumulation, and tau protein.

CURRENT ALZHEIMER RESEARCH (2021)

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Article Cell Biology

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Yasmine J. Liu et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

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Article Neurosciences

Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington's Disease

Emanuela Paldino et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Neurosciences

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Carolina Gubert et al.

NEUROBIOLOGY OF DISEASE (2020)

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Article Neurosciences

Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis

Marta Cherubini et al.

NEUROBIOLOGY OF DISEASE (2020)

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Article Biochemistry & Molecular Biology

Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats

Ghadha Ibrahim Fouad

NEUROCHEMICAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction

Rhia Ghosh et al.

FASEB JOURNAL (2020)

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Review Neurosciences

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

Wenzhang Wang et al.

MOLECULAR NEURODEGENERATION (2020)

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Review Cell Biology

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Guo Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Neurosciences

Development of early diagnosis of Parkinson's disease: Illusion or reality?

Michael Ugrumov

CNS NEUROSCIENCE & THERAPEUTICS (2020)

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Review Immunology

The role of innate immunity in Alzheimer's disease

Hannah E. Ennerfelt et al.

IMMUNOLOGICAL REVIEWS (2020)

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Review Biotechnology & Applied Microbiology

Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations

Samuele Maramai et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

SkQ1 Suppresses the p38 MAPK Signaling Pathway Involved in Alzheimer's Disease-Like Pathology in OXYS Rats

Natalia A. Muraleva et al.

ANTIOXIDANTS (2020)

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Article Cell Biology

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans

Xin Yang et al.

Aging-US (2020)

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Article Neurosciences

Upregulation of AMPK Ameliorates Alzheimer's Disease-Like Tau Pathology and Memory Impairment

Lin Wang et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Stephen C. Cunnane et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Multidisciplinary Sciences

Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells

Yousheng Cai et al.

SCIENTIFIC REPORTS (2020)

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Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1

Yuri Inose et al.

NEUROSCIENCE LETTERS (2020)

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Review Geriatrics & Gerontology

Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia

Ishan Agrawal et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Cell Biology

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Carla Lopes et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Defective mitophagy in Alzheimer's disease

Jangampalli Adi Pradeepkiran et al.

AGEING RESEARCH REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Peripheral Glycolysis in Neurodegenerative Diseases

Simon M. Bell et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Targeting Microglia for Therapy of Parkinson's Disease by Using Biomimetic Ultrasmall Nanoparticles

Hanghang Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling

Xiaokang Zeng et al.

NEURAL PLASTICITY (2020)

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Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease

Xinwen Zhang et al.

SCIENCE ADVANCES (2020)

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Review Neurosciences

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

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Review Neurosciences

Tau and DNA Damage in Neurodegeneration

Luca Colnaghi et al.

BRAIN SCIENCES (2020)

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Review Cell & Tissue Engineering

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

Pedro Norat et al.

NPJ REGENERATIVE MEDICINE (2020)

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Review Clinical Neurology

Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases

Panpan Yao et al.

EUROPEAN NEUROLOGY (2020)

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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Xufeng Cen et al.

NATURE COMMUNICATIONS (2020)

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Review Geriatrics & Gerontology

Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer's Disease

Kan Yin Wong et al.

AGING AND DISEASE (2020)

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Article Pharmacology & Pharmacy

Neuronal mitochondria-targeted therapy for Alzheimer's disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems

Yang Han et al.

DRUG DELIVERY (2020)

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LRRK2 and mitochondria: Recent advances and current views

Alpana Singh et al.

BRAIN RESEARCH (2019)

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Review Chemistry, Multidisciplinary

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Masha G. Savelieff et al.

CHEMICAL REVIEWS (2019)

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Article Immunology

Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors

Minhee Jang et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Review Neurosciences

Molecular Basis of Alzheimer's Disease: Focus on Mitochondria

Darryll M. A. Oliver et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Review Cell Biology

Microglia in Alzheimer's disease: A target for immunotherapy

Shoutang Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Immunology

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

Zhuo Gong et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Chemistry, Medicinal

Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway

Ji Hye Han et al.

MARINE DRUGS (2019)

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Article Neurosciences

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

Evandro F. Fang et al.

NATURE NEUROSCIENCE (2019)

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Article Neurosciences

Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

Taylor A. Intihar et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

Yuanyuan Zhao et al.

NATURE COMMUNICATIONS (2019)

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Article Pharmacology & Pharmacy

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP

Todd A. Johnson et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease

Sourav Samanta et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Article Neurosciences

Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer's disease

Hamidreza Komaki et al.

BRAIN RESEARCH BULLETIN (2019)

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Article Neurosciences

Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease

Niraj M. Shanbhag et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes

Ashim Paul et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Review Neurosciences

Emerging Perspectives on DNA Double-strand Breaks in Neurodegenerative Diseases

Ling-Shuang Zhu et al.

CURRENT NEUROPHARMACOLOGY (2019)

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Article Endocrinology & Metabolism

Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence

Sriranjini Venkata Rao et al.

METABOLIC BRAIN DISEASE (2019)

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Article Neurosciences

Mitochondria' dynamics and transport in Alzheimer's disease

Padraig J. Flannery et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2019)

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Article Cell Biology

Suppression of Alzheimer's Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study

Natalia A. Stefanova et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Pharmacology & Pharmacy

PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease

Fabiana Morroni et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Clinical Neurology

Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives

Chiara Lanzillotta et al.

CNS DRUGS (2019)

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Article Neurosciences

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

Melissa L. Young et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2019)

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Review Pharmacology & Pharmacy

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

Giovanna Cenini et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer's Disease

Sundas Hira et al.

BIOMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

Sofie Lautrup et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

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Article Cell Biology

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats

Muhammad Sohail Khan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice

Min Hee Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biochemistry & Molecular Biology

Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

Naufal Kushairi et al.

ANTIOXIDANTS (2019)

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Article Biochemistry & Molecular Biology

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Davide D'Amico et al.

MOLECULAR CELL (2019)

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Article Neurosciences

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Hongjun Fu et al.

NATURE NEUROSCIENCE (2019)

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Editorial Material Neurosciences

Editorial: Mitochondrial Dysfunction and Neurodegeneration

Victor Tapias

FRONTIERS IN NEUROSCIENCE (2019)

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Review Cell Biology

Multitarget therapeutic strategies for Alzheimer's disease

Mostafa M. Ibrahim et al.

NEURAL REGENERATION RESEARCH (2019)

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Article Biochemistry & Molecular Biology

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Dagmar E. Ehrnhoefer et al.

HUMAN MOLECULAR GENETICS (2018)

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Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Cell Biology

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

Michael G. Erkkinen et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage

K. Rajasekhar et al.

ACS CHEMICAL NEUROSCIENCE (2018)

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Article Cell Biology

The mitochondrial ATP synthase is a shared drug target for aging and dementia

Joshua Goldberg et al.

AGING CELL (2018)

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Article Biochemistry & Molecular Biology

Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster

Amos O. Abolaji et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

Ye Xi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Article Immunology

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

Zhenri Ou et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

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Article Immunology

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia

Gemma Navarro et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

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Article Cell Biology

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

Thomas G. McWilliams et al.

CELL METABOLISM (2018)

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Article Biochemistry & Molecular Biology

Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2

Laure-Estelle Cassagnes et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease

Xiao Zhou et al.

HUMAN MOLECULAR GENETICS (2018)

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Article Neurosciences

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease

P. Hemachandra Reddy et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Neurosciences

Mitochondria and Mitochondrial Cascades in Alzheimer's Disease

Russell H. Swerdlow

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Clinical Neurology

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

Susana Carmona et al.

LANCET NEUROLOGY (2018)

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Article Neurosciences

Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model

Regina Hertfelder Reynolds et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

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Article Neurosciences

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 x Tg-AD mouse model of Alzheimer's disease

Javier Frontinan-Rubio et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

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Article Neurosciences

Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes

Matheus B. Victor et al.

NATURE NEUROSCIENCE (2018)

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Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

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Article Neurosciences

Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology

Qin Zhang et al.

NEUROPHARMACOLOGY (2018)

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Article Clinical Neurology

The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future

Stanley Fahn

PARKINSONISM & RELATED DISORDERS (2018)

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Article Toxicology

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease

Hui Wang et al.

TOXICOLOGY LETTERS (2018)

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Review Chemistry, Multidisciplinary

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K. Rajasekhar et al.

RSC ADVANCES (2018)

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Article Clinical Neurology

Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

Fernando Bartolome et al.

ALZHEIMERS RESEARCH & THERAPY (2018)

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Review Neurosciences

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease

Sandra Franco-Iborra et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Review Pharmacology & Pharmacy

Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, alpha-synuclein, amyloid-beta and insulin resistance in neurodegenerative diseases

I. A. Clark et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Article Neurosciences

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

Bahareh Eftekharzadeh et al.

NEURON (2018)

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Review Biochemistry & Molecular Biology

The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease

Claus Desler et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Review Neurosciences

Advances in developing novel therapeutic strategies for Alzheimer's disease

Jiqing Cao et al.

MOLECULAR NEURODEGENERATION (2018)

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Review Geriatrics & Gerontology

TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism

Honghua Zheng et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Article Geriatrics & Gerontology

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

Meng-meng Jin et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Review Cell Biology

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

Saima Kausar et al.

CELLS (2018)

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Article Biochemistry & Molecular Biology

Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models

Young Cheol Kang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Article Neurosciences

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease

Bin Wu et al.

EXPERIMENTAL NEUROLOGY (2017)

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Article Biochemistry & Molecular Biology

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease

P. Hemachandra Reddy et al.

HUMAN MOLECULAR GENETICS (2017)

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Article Biochemistry & Molecular Biology

Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model

Wenzhang Wang et al.

HUMAN MOLECULAR GENETICS (2017)

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Article Clinical Neurology

Epidemiology of Parkinson's disease

Ole-Bjorn Tysnes et al.

JOURNAL OF NEURAL TRANSMISSION (2017)

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Article Immunology

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease

Charbel Moussa et al.

JOURNAL OF NEUROINFLAMMATION (2017)

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Article Neurosciences

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

Seung Hyun Baek et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Clinical Neurology

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Valery L. Feigin et al.

LANCET NEUROLOGY (2017)

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Article Neurosciences

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Maya Ando et al.

MOLECULAR NEURODEGENERATION (2017)

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Article Multidisciplinary Sciences

Structure of PINK1 in complex with its substrate ubiquitin

Alexander F. Schubert et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Polyglutamine tracts regulate beclin 1-dependent autophagy

Avraham Ashkenazi et al.

NATURE (2017)

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Article Cell Biology

Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

Shamsher Singh et al.

NEURAL REGENERATION RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants

Irene Lopez-Fabuel et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Article Neurosciences

Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement

XiaoLong Hu et al.

NEUROPHARMACOLOGY (2017)

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Article Multidisciplinary Sciences

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Luisa Quinti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease

Tatsuo Mano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Neurosciences

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

Jesse S. Kerr et al.

TRENDS IN NEUROSCIENCES (2017)

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Article Cell Biology

Pink1 interacts with alpha-synuclein and abrogates alpha-synuclein-induced neurotoxicity by activating autophagy

Jia Liu et al.

CELL DEATH & DISEASE (2017)

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Article Multidisciplinary Sciences

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Elias Bou Samra et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

En Huang et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

A synthetic cell permeable antioxidant protects neurons against acute oxidative stress

Nicola J. Drummond et al.

SCIENTIFIC REPORTS (2017)

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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

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Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients

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Review Biochemistry & Molecular Biology

Huntington's disease: degradation of mutant huntingtin by autophagy

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Letter Pharmacology & Pharmacy

Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease

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The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

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NEUROBIOLOGY OF DISEASE (2008)

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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BIOLOGICAL CHEMISTRY (2006)

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Mitochondria take center stage in aging and neurodegeneration

MF Beal

ANNALS OF NEUROLOGY (2005)

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Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant Huntingtin

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L Tau transgenic mice

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

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HUMAN MOLECULAR GENETICS (2004)

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Review Biochemistry & Molecular Biology

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CA Ross et al.

NATURE MEDICINE (2004)

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Review Medicine, Research & Experimental

A mitochondrial cascade hypthesis for sporadic Alzheimer's disease

RH Swerdlow et al.

MEDICAL HYPOTHESES (2004)

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Article Geriatrics & Gerontology

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

SM Cardoso et al.

NEUROBIOLOGY OF AGING (2004)

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Article Multidisciplinary Sciences

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

EM Valente et al.

SCIENCE (2004)

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Article Biochemistry & Molecular Biology

Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice

JD Lin et al.

CELL (2004)

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Article Biochemistry & Molecular Biology

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

F Darios et al.

HUMAN MOLECULAR GENETICS (2003)

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Article Neurosciences

Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons

S Chung et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2002)

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Article Cell Biology

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

K Stamer et al.

JOURNAL OF CELL BIOLOGY (2002)

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Article Clinical Neurology

The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

S Hoyer

JOURNAL OF NEURAL TRANSMISSION (2002)

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Article Neurosciences

Mitochondrial abnormalities in Alzheimer's disease

K Hirai et al.

JOURNAL OF NEUROSCIENCE (2001)

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Letter Neurosciences

Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease

Y Matsuoka et al.

NEUROSCIENCE (2001)

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