4.4 Article

Prognostic value of pretreatment diffusion-weighted imaging score for acute basilar artery occlusion with successful endovascular recanalization

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NEURORADIOLOGY
卷 65, 期 3, 页码 619-627

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SPRINGER
DOI: 10.1007/s00234-022-03090-w

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Acute stroke; Basilar artery; Diffusion-weighted imaging; Thrombectomy; Reperfusion

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The aim of this study was to test the prognostic value of a diffusion-weighted imaging score in acute basilar artery occlusion with successful recanalization. The results showed that the PMT score had the best prognostic value, and baseline National Institute of Health stroke scale and PMT score < 5 were independent prognostic factors of favorable outcome.
Purpose The aim of this study is to test the prognostic value of a diffusion-weighted imaging (DWI) score in acute basilar artery occlusion (ABAO) with successful recanalization. Methods The DWI-based pons-midbrain and thalamus (PMT) score was developed to assess posterior circulation infarcts. We test its prognostic value and compare it with other two established scales, the DWI-based posterior circulation acute stroke prognosis Early CT score (PC-ASPECTS) and brain stem score (BSS). A retrospective cohort of consecutive ABAO patients with pretreatment magnetic resonance imaging and successful recanalization (defined as modified Thrombolysis in Cerebral Infarction 2b-3) were analyzed. A favorable outcome was defined as a 90-day modified Rankin Scale (mRS) score of 2 or less. The prognostic performance of three scales was estimated by receiver operating characteristic (ROC) curve analyses. Results One hundred and sixteen eligible patients (mean age, 59.1 +/- 11.7 [standard deviation]; 96 [82.8%] man) were included and evaluated. Between favorable (mRS <= 2) and unfavorable groups, the baseline PMT score (median [interquartile range], 3 [1-4] versus 6 [5-8]; P < 0.001) differs significantly. ROC curve analyses showed the PMT score had the best prognostic value for favorable outcome (area under the curve, PMT versus BSS versus PC-ASPECTS = 0.80 versus 0.72 versus 0.68, P = 0.010). Multivariate logistic regression analyses showed baseline National Institute of Health stroke scale (OR, 0.90 [95%CI, 0.86-0.95], P = 0.004) and PMT score < 5 (OR, 17.83 [95%CI, 3.91-81.19], P < 0.001) were independent prognostic factors of favorable outcome. Conclusions The PMT score seems to predict clinical outcome of ABAO patients with successful recanalization.

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