Understanding the Role of the Choroid Plexus in Multiple Sclerosis as an MRI Biomarker of Disease Activity

Article Clinical Neurology

Association of Choroid Plexus Inflammation on MRI With Clinical Disability Progression Over 5 Years in Patients With Multiple Sclerosis

Niels Bergsland et al.

Summary: This study found a correlation between increased volume and inflammation of the choroid plexus (CP) and clinical disability progression in patients with multiple sclerosis (MS).

NEUROLOGY (2023)

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Article Clinical Neurology

Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder A Retrospective, Cross-sectional Analysis

Jannis Muller et al.

Summary: This study found that the choroid plexus volume was larger in patients with MS compared to those with NMOSD, healthy controls, and migraine patients. In contrast to NMOSD, the volume of the choroid plexus in MS was associated with the number of T2-weighted lesions.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

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Article Clinical Neurology

Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy

Samuel Klistorner et al.

Summary: This study found a strong association between baseline choroid plexus volume and subsequent expansion of chronic periventricular multiple sclerosis (MS) lesions and associated tissue damage, but no correlation with volume of new lesions.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Choroid Plexus Enlargement in Inflammatory Multiple Sclerosis: 3.0-T MRI and Translocator Protein PET Evaluation

Vito A. G. Ricigliano et al.

Summary: This study found that the choroid plexuses (CPs) in patients with MS are significantly enlarged and inflamed, particularly in those with inflammatory profiles such as RRMS.

RADIOLOGY (2021)

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Article Multidisciplinary Sciences

Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

Vinzenz Fleischer et al.

Summary: The enlargement of ChP is closely associated with acute disease activity in both studied mouse models and humans, suggesting it as a potential interspecies marker for neuroinflammation that relates to functional impairment. Pharmacological modulation of the blood-CSF barrier with natalizumab prevents ChP volume increase and shows a close dependency of ChP integrity on molecular signatures of neuroinflammation. These findings suggest ChP characteristics as robust and translatable hallmarks of acute and ongoing neuroinflammatory activity in mice and humans.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Clinical Neurology