Blood Pressure and Risk of Dementia in Parkinson Disease and Multiple System Atrophy Should You Buy the Dip in Such a Volatile Market?

Article Clinical Neurology

Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy

Inigo Ruiz Barrio et al.

Summary: This study aims to evaluate the association between orthostatic hypotension (OH) and dementia risk in patients with Parkinson disease (PD), as well as cognitive impairment risk in patients with multiple system atrophy (MSA). The study found that early OH increases the risk of cognitive impairment in patients with PD and MSA, but not its symptom severity. Further research is needed to determine if treating OH can modify the risk of dementia in these conditions.

NEUROLOGY (2023)

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Article Clinical Neurology

Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels

Ilaria Cani et al.

Summary: This study aims to disclose the nature of cognitive deficits in patients with idiopathic autonomic failure (IAF) and explore their relation to cardiovascular autonomic failure (AF) and phenoconversion. The results showed that approximately 43% of IAF patients displayed cognitive deficits, mainly affecting executive functioning. The presence of cognitive deficits was not associated with phenoconversion or autonomic function parameters, but correlated with cerebral white matter hyperintensities (WMH) load and neurofilament light chain (NfL) levels.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

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Review Urology & Nephrology

Hypertension-induced cognitive impairment: from pathophysiology to public health

Zoltan Ungvari et al.

Summary: Hypertension has significant impacts on cerebral microcirculation which can lead to cognitive impairment, especially in the elderly. Interventions targeting blood pressure reduction, lifestyle changes, and promoting microvascular health have the potential to prevent or delay vascular cognitive impairment and Alzheimer's disease in hypertensive patients.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Medicine, General & Internal