期刊
NEUROLOGICAL SCIENCES
卷 -, 期 -, 页码 -出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-023-06599-x
关键词
Secondary insult; Acute ischemic stroke; Endovascular treatment; Posterior occlusion; Anterior occlusion; Anesthesia
This study observed patients undergoing endovascular treatment for acute ischemic stroke and found that 78% of patients experienced hypotension, 21% experienced hypertension, 54% experienced hypoxemia, 16% experienced bradycardia, and 13% experienced tachycardia. Additionally, 70% of patients experienced hypocapnia and 21% experienced hypercapnia. Although these secondary insults played a role in prognosis, age, NIHSS at admission, and successful recanalization were the main predictors of outcome.
BackgroundNeurological outcome after endovascular treatment (EVT) of acute ischemic stroke (AIS) may depend on both patient-specific and procedural factors. We hypothesized that altered systemic homeostasis might be frequent and affect outcome in these patients. The aim of this study was to analyze secondary insults during EVT of AIS and its association with outcome and anesthesiologic regimen.MethodsThis was a single-center prospective observational study on patients undergoing EVT for AIS under local anesthesia (LA), conscious sedation (CS), or general anesthesia (GA). Altered systemic parameters were recorded and quantified as secondary insults. The primary endpoint was to evaluate number, duration, and severity of secondary insults during EVT. Secondary endpoints were to analyze association of insults with modified Rankin Scale at 90 days and anesthesiologic regimen.Results and conclusionsOne hundred twenty patients were enrolled. Overall, 78% of patients experienced at least one episode of hypotension, 21% hypertension, 54% hypoxemia, 16% bradycardia, and 13% tachycardia. In patients monitored with capnometry, 70% experienced hypocapnia and 21% hypercapnia. LA was selected in 24 patients, CS in 84, and GA in 12. Hypotension insult was more frequent during GA than LA and CS (p = 0.0307), but intraprocedural blood pressure variation was higher during CS (p = 0.0357). Hypoxemia was more frequent during CS (p = 0.0087). Proportion of hypotension duration was higher in unfavorable outcome but secondary insults did not remain in the final model of multivariable analysis. Secondary insults occurred frequently during EVT for AIS but the main predictors of outcome were age, NIHSS at admission, and prompt and successful recanalization.
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