期刊
NEUROIMAGE
卷 265, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119773
关键词
Sulcal morphology; Human gained enhancers; Neuroimaging; Genome-wide association; Evolution
The expansion of the cerebral cortex and increases in cortical folding contribute to our high-order cognitive abilities. Through molecular analysis, we identified evolutionary changes in chromosomal regions in humans and primates. In this study, genomic annotations spanning 30 million years were shown to have an impact on human sulcal morphology, particularly in areas linked to locomotion and bipedalism.
The expansion of the cerebral cortex is one of the most distinctive changes in the evolution of the human brain. Cortical expansion and related increases in cortical folding may have contributed to emergence of our capacities for high-order cognitive abilities. Molecular analysis of humans, archaic hominins, and non-human primates has allowed identification of chromosomal regions showing evolutionary changes at different points of our phylo-genetic history. In this study, we assessed the contributions of genomic annotations spanning 30 million years to human sulcal morphology measured via MRI in more than 18,000 participants from the UK Biobank. We found that variation within brain-expressed human gained enhancers, regulatory genetic elements that emerged since our last common ancestor with Old World monkeys, explained more trait heritability than expected for the left and right calloso-marginal posterior fissures and the right central sulcus. Intriguingly, these are sulci that have been previously linked to the evolution of locomotion in primates and later on bipedalism in our hominin ancestors.
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