期刊
NEUROCHEMISTRY INTERNATIONAL
卷 162, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2022.105453
关键词
Parkinson?s disease; Heat shock proteins; ?-Synuclein; PROTAC; Oxidative stress
Parkinson's disease is a common chronic neurodegenerative disease, and heat shock proteins play important roles in this disease by maintaining protein homeostasis, degrading aggregates, promoting autophagy, and inhibiting neuronal apoptosis.
Parkinson's disease (PD) is a common chronic neurodegenerative disease, and the heat shock proteins (HSPs) are proved to be of great value for PD. In addition, HSPs can maintain protein homeostasis, degrade and inhibit protein aggregation by properly folding and activating intracellular proteins in PD. This study mainly summa-rizes the important roles of HSPs in PD and explores their feasibility as targets. We introduced the structural and functional characteristics of HSPs and the physiological functions of HSPs in PD. HSPs can protect neurons from damage by degrading aggregates with three mechanisms, including the aggregation and removing alpha-Synuclein (alpha-Syn) aggregates, promotion the autophagy of abnormal proteins, and inhibition the apoptosis of degenerated neurons. This study underscores the importance of HSPs as targets in PD and helps to expand new mechanisms in PD treatment strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据