期刊
NEUROBIOLOGY OF DISEASE
卷 177, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2023.105999
关键词
Epilepsy; Interictal; High-frequency oscillations; Interictal spikes; Slow waves; Infraslow oscillations
In this review, the authors briefly describe the electrographic characteristics of high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs) in the interictal state, and discuss their various roles in epilepsy. They summarize representative evidence from experimental and clinical epilepsy to address their critical roles in seizure generation and epileptogenesis, indicating their potential as electrophysiological biomarkers of epilepsy. Importantly, they propose perspectives for further research in the field.
Interictal electroencephalogram (EEG) patterns, including high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs), are defined as specific oscillations between seizure events. These interictal oscillations reflect specific dynamic changes in network excitability and play various roles in epilepsy. In this review, we briefly describe the electrographic characteristics of HFOs, ISs, and SWAs in the interictal state, and discuss the underlying cellular and network mechanisms. We also summarize representative evidence from experimental and clinical epilepsy to address their critical roles in ictogenesis and epileptogenesis, indicating their potential as electrophysiological biomarkers of epilepsy. Importantly, we put forwards some perspectives for further research in the field.
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