期刊
CELL
卷 163, 期 2, 页码 292-300出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.09.041
关键词
-
资金
- National Institutes of Health [R01 GM46779, R01 NS079415, U54 082013, R01 GM080465]
Among the three phases of mRNA translation-initiation, elongation, and termination-initiation has traditionally been considered to be rate limiting and thus the focus of regulation. Emerging evidence, however, demonstrates that control of ribosome translocation (polypeptide elongation) can also be regulatory and indeed exerts a profound influence on development, neurologic disease, and cell stress. The correspondence of mRNA codon usage and the relative abundance of their cognate tRNAs is equally important for mediating the rate of polypeptide elongation. Here, we discuss recent results showing that ribosome pausing is a widely used mechanism for controlling translation and, as a result, biological transitions in health and disease.
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