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Molecular approaches for spinal cord injury treatment

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Article Neurosciences

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury

Brett J. Hilton et al.

Summary: Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury due to the inhibitory effects of critical components of the presynaptic active zone. The acquisition of axon regeneration ability leads to downregulation of molecular constituents of the synapse in adult sensory neurons. Specific presynaptic active zone proteins inhibit axon regeneration, while Baclofen promotes regeneration by reducing calcium influx.

NEURON (2022)

Article Critical Care Medicine

Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury

Nidia de Sousa et al.

Summary: Spinal cord injury affects millions of people worldwide, leading to severe motor and sensory impairments. Spasticity is a common neurological complication in SCI, and its management can be achieved through various approaches, with baclofen being the most effective drug. Recent data suggest that baclofen may also have a neuroprotective role in SCI, offering promise for developing new pharmacological strategies for functional recovery.

JOURNAL OF NEUROTRAUMA (2022)

Review Pharmacology & Pharmacy

A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury

Nader Hejrati et al.

Summary: This review provides a comprehensive summary of the most promising neuroprotective and neuroregenerative therapies under investigation, with a particular focus on neuroregenerative treatments such as neuropharmacological and cell-based approaches. Exciting investigational areas of biomaterial scaffolds and neuromodulation therapies are also highlighted.

CURRENT OPINION IN PHARMACOLOGY (2021)

Article Critical Care Medicine

Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research

Leslie R. Morse et al.

Summary: Over the past decade, the spinal cord injury research community has made significant advances and hosted a conference to discuss how to continue advancing research for the benefit of patients. The conference brought together stakeholders such as researchers, clinicians, patients, and industry partners to break down communication barriers and support collaboration to promote spinal cord injury research and clinical options.

JOURNAL OF NEUROTRAUMA (2021)

Article Neurosciences

The protective effect and mechanism of COA-Cl in acute phase after spinal cord injury

Issei Sakamoto et al.

Summary: COA-Cl administration in the acute phase of SCI exerts neuroprotective effects via the ERK pathway, leading to the recovery of motor function.

NEUROSCIENCE RESEARCH (2021)

Review Anesthesiology

Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis

Christine Hunt et al.

Summary: This systematic review and meta-analysis aimed to determine the prevalence of chronic pain after SCI based on the ISCIP system. The overall prevalence of chronic pain in SCI was found to be 68%, with neuropathic pain at 58%, musculoskeletal pain at 56%, visceral pain at 20%, and nociceptive pain at 45%. Certainty in prevalence estimates was judged to be low due to unexplained heterogeneity.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2021)

Article Cell & Tissue Engineering

Combined treatment with enteric neural stem cells and chondroitinase ABC reduces spinal cord lesion pathology

Benjamin Jevans et al.

Summary: The combination treatment of enteric neural stem cells (ENSCs) with chondroitinase ABC (ChABC) showed superior regenerative effects in repairing spinal cord injury, suggesting a potential new strategy for treating SCI.

STEM CELL RESEARCH & THERAPY (2021)

Article Biophysics

A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release

Xiaoli Song et al.

Summary: The research developed a sandwich structured composite membrane through electrospray for longtime controlled release of NGF to repair SCI, showing good biocompatibility and potential. The composite membrane can be directly applied to the injured areas without further damage, while the longtime sustained release of NGF guarantees enough repair time.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Biochemistry & Molecular Biology

Blocking the EGFR/p38/NF-κB signaling pathway alleviates disruption of BSCB and subsequent inflammation after spinal cord injury

Zai-Wang Li et al.

Summary: The activation of EGFR in main cellular components of BSCB after SCI mediates BSCB disruption and secondary inflammatory injury via the EGFR/p38/NF-kappa B pathway. Inactivation of EGFR or p38 inhibits NF-kappa B nuclear translocation, reduces production of pro-inflammatory factors, and preserves TJ proteins, thereby mitigating the secondary injury after SCI.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Critical Care Medicine

A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury

Michael G. Fehlings et al.

Summary: This study assessed the efficacy and safety of the Rho inhibitor VX-210 in patients with acute traumatic cervical SCI, but an interim analysis showed futility, leading to premature termination of the study. The primary efficacy end-point was not achieved in the final analysis.

JOURNAL OF NEUROTRAUMA (2021)

Review Neurosciences

Bibliometric Study of Pain after Spinal Cord Injury

Yi-Zu Wang et al.

Summary: This study analyzed the global trends of research on the comorbidity of pain after SCI from 1990 to 2019, revealing a significant increase in publications with a focus on clinical neurology, neurosciences, and rehabilitation. The USA and the University of Miami were the countries and institutions with the highest number of publications, highlighting research trends on individuals, inflammation, and central sensitization in the field.

NEURAL PLASTICITY (2021)

Article Neurosciences

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Peer B. Jacobson et al.

Summary: Spinal cord injury is a devastating condition with limited treatment options. Research has shown that utilizing the human anti-RGMa monoclonal antibody elezanumab can promote neuroprotection and neuroplasticity.

NEUROBIOLOGY OF DISEASE (2021)

Article Cell Biology

AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats

Sipin Zhu et al.

Summary: The study demonstrates that treatment with AAV2-5HRE-bFGF-NSCs improves recovery in SCI rats by increasing bFGF expression, promoting neural-specific protein expression, inhibiting glial scar formation, and reducing cell autophagy. This approach shows promise in future clinical trials for SCI repair.

CELL DEATH & DISEASE (2021)

Article Pharmacology & Pharmacy

M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway

Ziyu Li et al.

Summary: The study reveals that macrophages M2 polarization can secrete PDGFB to act on PDGFR beta, promoting the migration of PDGFR beta(+) pericytes, providing a promising new target for the treatment of SCI.

FRONTIERS IN PHARMACOLOGY (2021)

Article Engineering, Biomedical

Nerve growth factor loaded macrophage-derived nanovesicles for inhibiting neuronal apoptosis after spinal cord injury

Nan Xia et al.

Summary: Nanovesicles encapsulating NGF (NGF-NVs) derived from macrophage membrane were prepared as a drug carrier for SCI treatment, showing promising effects in both cell and animal experiments.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

Article Cell & Tissue Engineering

Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Feifei Huang et al.

Summary: The study showed that bFGF-overexpressing HUCMSCs met clinical safety standards and significantly improved therapeutic outcomes in a mouse SCI model. This included reducing glial scar formation, enhancing nerve regeneration and NSC proliferation, and improving locomotion function recovery. Additionally, bFGF-overexpressing HUCMSCs promoted NSC proliferation and neuronal differentiation in vitro through the PI3K-Akt-GSK-3 beta pathway, supporting the safety and efficacy of gene-modified MSCs for clinical use.

STEM CELL RESEARCH & THERAPY (2021)

Article Orthopedics

The Clinical Effect of a Combination of Mouse Nerve Growth Factor and Methylcobalamin to Treat Lumbar Disc Herniation with Foot Drop: A Retrospective Cohort Study

Zhuang Chen-yang et al.

Summary: The study found that mNGF had clinical effects on promoting the recovery of neurological function in patients with LDH accompanied by foot drop. The combination treatment of mNGF and MeCbl was more effective in improving sensory and muscular strength in patients with LDH compared to MeCbl alone.

ORTHOPAEDIC SURGERY (2021)

Article Biochemistry & Molecular Biology

miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway

Yining Zhang et al.

Summary: Our study found that miR-21a-5p has effects on the induction of A1 astrocytes and revealed the potential mechanism. Additionally, CNTF was shown to inhibit the transformation of naive astrocytes into A1s.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Cell Biology

Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury

Lu-Xia Ye et al.

Summary: The study revealed that platelet-derived growth factor can promote endothelial cell repair, regulate autophagy, improve the function of the blood-spinal cord barrier, and facilitate the recovery of locomotor function post-spinal cord injury.

NEURAL REGENERATION RESEARCH (2021)

Review Cell Biology

FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency

Majid Mossahebi-Mohammadi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Sialidase substrates for Sialdiase assays-activity, specificity, quantification and inhibition

Lei Yuan et al.

GLYCOCONJUGATE JOURNAL (2020)

Review Biochemistry & Molecular Biology

Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain

Fabrizio Vincenzi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Clinical Neurology

A Longitudinal Study of the Neurologic Safety of Acute Baclofen Use After Spinal Cord Injury

Jacquelyn J. Cragg et al.

NEUROTHERAPEUTICS (2019)

Review Cell Biology

Fibroblast growth factors in the management of spinal cord injury

Yulong Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Critical Care Medicine

Epidermal growth factor regulates apoptosis and oxidative stress in a rat model of spinal cord injury

Anil Murat Ozturk et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2018)

Review Physiology

PHARMACOLOGY OF ADENOSINE RECEPTORS: THE STATE OF THE ART

Pier Andrea Borea et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Neurosciences

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Vera Clemens et al.

BMC NEUROSCIENCE (2018)

Review Cell Biology

Inosine - a Multifunctional Treatment for Complications of Neurologic Injury

Claire Doyle et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Critical Care Medicine

Minocycline Reduces the Severity of Autonomic Dysreflexia after Experimental Spinal Cord Injury

Jordan W. Squair et al.

JOURNAL OF NEUROTRAUMA (2018)

Article Multidisciplinary Sciences

Required growth facilitators propel axon regeneration across complete spinal cord injury

Mark A. Anderson et al.

NATURE (2018)

Article Clinical Neurology

First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury

Klaus Kucher et al.

NEUROREHABILITATION AND NEURAL REPAIR (2018)

Review Cell Biology

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Przemyslaw Kowianski et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)

Article Cell Biology

RhoA/Rho kinase in spinal cord injury

Xiangbing Wu et al.

NEURAL REGENERATION RESEARCH (2016)

Review Neurosciences

Purine nucleosides in neuroregeneration and neuroprotection

Filipa F. Ribeiro et al.

NEUROPHARMACOLOGY (2016)

Article Multidisciplinary Sciences

The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair

Vedangana Saini et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

Sarah Pasquin et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Article Multidisciplinary Sciences

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Bradley T. Lang et al.

NATURE (2015)

Article Multidisciplinary Sciences

Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury

Yeun Goo Chung et al.

PLOS ONE (2015)

Article Neurosciences

Chronic spinal cord lesions respond positively to tranplants of mesenchymal stem cells

Fernanda Martins de Almeida et al.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE (2015)

Review Neurosciences

Nogo limits neural plasticity and recovery from injury

Martin E. Schwab et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

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Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury

Alice Gaudin et al.

NATURE NANOTECHNOLOGY (2014)

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Oral administration of inosine promotes recovery after experimental spinal cord injury in rat

Maria Kuricova et al.

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Global prevalence and incidence of traumatic spinal cord injury

Anoushka Singh et al.

CLINICAL EPIDEMIOLOGY (2014)

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Sialidase, Chondroitinase ABC, and Combination Therapy after Spinal Cord Contusion Injury

Andrea Mountney et al.

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Riluzole: What It Does to Spinal and Brainstem Neurons and How It Does It

Alessandra Cifra et al.

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Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury

Daniel Kim et al.

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The glial scar in spinal cord injury and repair

Yi-Min Yuan et al.

NEUROSCIENCE BULLETIN (2013)

Review Biochemistry & Molecular Biology

Antioxidant therapies in traumatic brain and spinal cord injury

Mona Bains et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

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Acute Treatment Options for Spinal Cord Injury

Manjunath Markandaya et al.

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Therapeutic approaches for spinal cord injury

Alexandre Fogaca Cristante et al.

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Pregabalin as a Neuroprotector after Spinal Cord Injury in Rats: Biochemical Analysis and Effect on Glial Cells

Kee-Yong Ha et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2011)

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Human Dental Pulp Cells: A New Source of Cell Therapy in a Mouse Model of Compressive Spinal Cord Injury

Fernanda Martins de Almeida et al.

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Antioxidant Therapies for Acute Spinal Cord Injury

Edward D. Hall

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FGF-2 Modulates Wnt Signaling in Undifferentiated hESC and iPS Cells Through Activated PI3-K/GSK3β Signaling

Vanessa M. Y. Ding et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2010)

Article Biotechnology & Applied Microbiology

Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice

Ali Mehanna et al.

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Article Multidisciplinary Sciences

Sialidase enhances recovery from spinal cord contusion injury

Andrea Mountney et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

Guillermo Garcia-Alias et al.

NATURE NEUROSCIENCE (2009)

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Role of platelet-derived growth factors in physiology and medicine

Johanna Andrae et al.

GENES & DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Metabolism and distribution of guanosine given intraperitoneally: Implications for spinal cord injury

Shucui Jiang et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2008)

Article Biochemistry & Molecular Biology

Neurotrophic effects of extracellular guanosine

Michel Rathbone et al.

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Functional evolutionary history of the mouse Fgf gene family

Nobuyuki Itoh et al.

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Article Medicine, Research & Experimental

Endothelial sulfonylurea receptor 1-regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury

J. Marc Simard et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Cell Biology

Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat

Dasa Cizkova et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2006)

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Glial inhibition of CNS axon regeneration

Glenn Yiu et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Neurosciences

Therapeutic interventions after spinal cord injury

Sandrine Thuret et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Sialidase enhances spinal axon outgrowth in vivo

Lynda J. S. Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro

AA Vyas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS

PS Sapieha et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2005)

Review Neurosciences

Degenerative and regenerative mechanisms governing spinal cord injury

C Profyris et al.

NEUROBIOLOGY OF DISEASE (2004)

Review Pharmacology & Pharmacy

Immunomodulatory and neuroprotective effects of inosine

G Haskó et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)

Article Critical Care Medicine

Targeting recovery: Priorities of the spinal cord-injured population

KD Anderson

JOURNAL OF NEUROTRAUMA (2004)

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Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration

AA Vyas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Chondroitinase ABC promotes functional recovery after spinal cord injury

EJ Bradbury et al.

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Regulation of cell survival by secreted proneurotrophins

R Lee et al.

SCIENCE (2001)

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Neurotrophins: Roles in neuronal development and function

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ANNUAL REVIEW OF NEUROSCIENCE (2001)