期刊
CELL
卷 162, 期 3, 页码 662-674出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.06.058
关键词
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资金
- EUREKA NIDA [R01DA037152]
- NIMH [F31 MH101956]
- NIDA [K99DA038725]
- National Security Science and Engineering Faculty Fellowship of Energy
- US Department of Energy, Division of Materials Sciences [DE-FG02-07ER46471]
- NIH Common Fund NINDS [R01NS081707]
- Materials Research Laboratory and Center for Microanalysis of Materials [DE-FG02-07ER46453]
In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, un-tethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (m-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.
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