Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)

A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line.

Automated summary

A new series of chalcones has been developed for potential use in treating lung cancer. Spectral tools were used to confirm the existence of the new series, and MTT assay and molecular docking studies were conducted to evaluate their cytotoxic and apoptotic effects on lung cancer cells.