4.5 Article

Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer

期刊

NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 29, 期 11, 页码 1040-1042

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41594-022-00858-9

关键词

-

资金

  1. US National Institutes of Health [5T32GM133351, R01 CA228211]
  2. Pew-Stewart Scholars for Cancer Research
  3. American Cancer Society Research Scholar Award

向作者/读者索取更多资源

Recent research reveals that the CoREST complex plays a crucial role in regulating the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data demonstrate that this resistance transition is associated with the functional retargeting of CoREST on chromatin, which occurs in coordination with cJUN and SWI/SNF (cBAF).
New research shows that the CoREST complex controls the acquisition of endocrine therapy resistance in estrogen receptor-positive breast cancers. Profiling data show that this resistance transition is accompanied by a functional retargeting of CoREST on chromatin in coordination with cJUN and SWI/SNF (cBAF).

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据