Neurotoxic effects of air pollution: an urgent public health concern

Review Pharmacology & Pharmacy

Air Pollution-Related Neurotoxicity Across the Life Span

Deborah A. Cory-Slechta et al.

Summary: Air pollution is a complex mixture that exposes individuals to a lifelong exposure of gases, particulate matter, and contaminants. Studies increasingly associate air pollution with neurodevelopmental disorders and neurodegenerative diseases, supported by animal models. The shared mechanisms of inflammation, oxidative stress, and brain metal dyshomeostasis across these diseases highlight the need for future research to identify responsible contaminants and protect public health.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2023)

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Article Biochemistry & Molecular Biology

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders

Samuel David et al.

Summary: This review examines the mechanisms that control cellular iron homeostasis, the dysregulation of these mechanisms in neurological disorders, and recent research on how iron-induced tissue damage occurs via ferroptosis.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Article Developmental Biology

Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy

J. N. D'Errico et al.

Summary: This study evaluated the distribution of inhaled titanium dioxide nanoparticles from maternal lung to maternal and fetal systemic tissues in pregnant rats and found extrapulmonary distribution of titanium to various maternal organs during pregnancy. The study also identified systemic distribution and placental accumulation of titanium after nano-TiO2 aerosol inhalation in a pregnancy model, arousing concerns for poor air quality for pregnant women and possible contributions to adverse pregnancy outcomes.

PLACENTA (2022)

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Review Biochemistry & Molecular Biology

Particulate matter and Alzheimer?s disease: an intimate connection

Devin R. O'Piela et al.

Summary: The role of the environment in disease progression has been recognized for decades, but understanding how airborne toxicant exposure can affect organs beyond the lungs is an area of scientific inquiry that has been overlooked. This review summarizes the knowns and unknowns of the relationship between particulate matter exposure and Alzheimer's disease progression.

TRENDS IN MOLECULAR MEDICINE (2022)

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Review Environmental Sciences

Association between exposure to ambient particulate matters and risks of autism spectrum disorder in children: a systematic review and exposure-response meta-analysis

Cheng-Kuan Lin et al.

Summary: The study reviewed the impact of prenatal and early childhood exposure to ambient particulate matters on the risk of autism spectrum disorder in children, finding a positive association between PM2.5 exposure and ASD risk.

ENVIRONMENTAL RESEARCH LETTERS (2021)

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Review Biochemistry & Molecular Biology