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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimers disease neurons: implications for mitochondrial dysfunction and neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2012)
The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
Megan Larson et al.
JOURNAL OF NEUROSCIENCE (2012)
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease
M. Watabe-Rudolph et al.
NEUROLOGY (2012)
MEK Is a Key Regulator of Gliogenesis in the Developing Brain
Xiaoyan Li et al.
NEURON (2012)
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
Alix de Calignon et al.
NEURON (2012)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
Trans-Synaptic Spread of Tau Pathology In Vivo
Li Liu et al.
PLOS ONE (2012)
Inhibition of Soluble Tumor Necrosis Factor Ameliorates Synaptic Alterations and Ca2+ Dysregulation in Aged Rats
Diana M. Sama et al.
PLOS ONE (2012)
Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits
Julie A. Harris et al.
PLOS ONE (2012)
Amyloid-β Peptide Binds to Cytochrome C Oxidase Subunit 1
Luis Fernando Hernandez-Zimbron et al.
PLOS ONE (2012)
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease
Marc Aurel Busche et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Soluble forms of tau are toxic in Alzheimer's disease
Katherine J. Kopeikina et al.
TRANSLATIONAL NEUROSCIENCE (2012)
Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain
Katherine J. Kopeikina et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Amyloid Precursor Protein Processing and Alzheimer's Disease
Richard J. O'Brien et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)
Chemokines in CSF of Alzheimer's disease patients
Joice Dias Correa et al.
ARQUIVOS DE NEURO-PSIQUIATRIA (2011)
PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
Jarin Hongpaisan et al.
JOURNAL OF NEUROSCIENCE (2011)
Alzheimer's Disease Brain-Derived Amyloid-β-Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein
Andrew E. Barry et al.
JOURNAL OF NEUROSCIENCE (2011)
Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant
Astrid Sydow et al.
JOURNAL OF NEUROSCIENCE (2011)
Amyloid-β/Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
Erik D. Roberson et al.
JOURNAL OF NEUROSCIENCE (2011)
The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
Paula L. McClean et al.
JOURNAL OF NEUROSCIENCE (2011)
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Cristian A. Lasagna-Reeves et al.
MOLECULAR NEURODEGENERATION (2011)
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
Moustapha Cisse et al.
NATURE (2011)
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
Marcello D'Amelio et al.
NATURE NEUROSCIENCE (2011)
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Adam W. Bero et al.
NATURE NEUROSCIENCE (2011)
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors
Raik Roenicke et al.
NEUROBIOLOGY OF AGING (2011)
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice
Anete Rozkalne et al.
NEUROBIOLOGY OF DISEASE (2011)
Cerebrospinal Fluid Microglial Markers in Alzheimer's Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility
Niklas Mattsson et al.
NEUROMOLECULAR MEDICINE (2011)
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
Ming Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa C. Paolicelli et al.
SCIENCE (2011)
Cerebrospinal fluid and blood biomarkers in Alzheimer's disease
Christian Humpel et al.
WORLD JOURNAL OF PSYCHIATRY (2011)
YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
Rebecca Craig-Schapiro et al.
BIOLOGICAL PSYCHIATRY (2010)
The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?
Stanley E. Lazic
BMC NEUROSCIENCE (2010)
The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
Jessica M. Mc Donald et al.
BRAIN (2010)
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Lars M. Ittner et al.
CELL (2010)
Neuronal caspase-3 signaling: not only cell death
M. D'Amelio et al.
CELL DEATH AND DIFFERENTIATION (2010)
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
Peer-Hendrik Kuhn et al.
EMBO JOURNAL (2010)
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
A. B. Rocher et al.
EXPERIMENTAL NEUROLOGY (2010)
β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels
Hyunbum Jang et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation
Hai-Yan Wu et al.
JOURNAL OF NEUROSCIENCE (2010)
Amyloid beta from axons and dendrites reduces local spine number and plasticity
Wei Wei et al.
NATURE NEUROSCIENCE (2010)
Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5
Marianne Renner et al.
NEURON (2010)
Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
Brian R. Hoover et al.
NEURON (2010)
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model
Anete Rozkalne et al.
BRAIN RESEARCH (2009)
Memantine and Acetylcholinesterase Inhibitor Treatment in Cases of CDR 0.5 or Questionable Impairment
Mckee J. McClendon et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer
Rakez Kayed et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening
Heidi K. Baumgartner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The amyloid hypothesis for Alzheimer's disease: a critical reappraisal
John Hardy
JOURNAL OF NEUROCHEMISTRY (2009)
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
Juha Lauren et al.
NATURE (2009)
Transmission and spreading of tauopathy in transgenic mouse brain
Florence Clavaguera et al.
NATURE CELL BIOLOGY (2009)
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
S. Hauptmann et al.
NEUROBIOLOGY OF AGING (2009)
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
Tara L. Spires Jones et al.
NEUROBIOLOGY OF DISEASE (2009)
Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
Reisa A. Sperling et al.
NEURON (2009)
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Robert M. Koffie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
Natalia Louneva et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
Jeffrey A. Fein et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Amyloid beta oligomers induce impairment of neuronal insulin receptors
Wei-Qin Zhao et al.
FASEB JOURNAL (2008)
Amyloid-β binds to the extracellular cysteine-rich domain of frizzled and inhibits wnt/β-catenin signaling
Margaret H. Magdesian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells
A. Gomez-Ramos et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo
John R. Cirrito et al.
NEURON (2008)
Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks
Kishore V. Kuchibhotla et al.
NEURON (2008)
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Camilla A. Hansson Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Caldendrin-Jacob: A protein liaison that couples NMDA receptor signalling to the nucleus
Daniela C. Dieterich et al.
PLOS BIOLOGY (2008)
Novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
Lenka Munoz et al.
JOURNAL OF NEUROINFLAMMATION (2007)
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm
Ratnesh Lal et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
Erik D. Roberson et al.
SCIENCE (2007)
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
S. W. Scheff et al.
NEUROLOGY (2007)
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
Ganesh M. Shankar et al.
JOURNAL OF NEUROSCIENCE (2007)
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Yasumasa Yoshiyama et al.
NEURON (2007)
A ganglioside-induced toxic soluble Aβ assembly -: Its enhanced formation from Aβ bearing the Arctic mutation
Naoki Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits
Wenhui Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Carlo Ballatore et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Astrocytic complexity distinguishes the human brain
Nancy Ann Oberheim et al.
TRENDS IN NEUROSCIENCES (2006)
Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host
Melanie Meyer-Luehmann et al.
SCIENCE (2006)
Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity:: a potent role for trimers
M Townsend et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Astrocyte-endothelial interactions at the blood-brain barrier
NJ Abbott et al.
NATURE REVIEWS NEUROSCIENCE (2006)
The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention
DM Walsh et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death
C Costantini et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2005)
Natural oligomers of the amyloid-protein specifically disrupt cognitive function
JP Cleary et al.
NATURE NEUROSCIENCE (2005)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
MD Greicius et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Synaptic targeting by Alzheimer's-related amyloid β oligomers
PN Lacor et al.
JOURNAL OF NEUROSCIENCE (2004)
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2
E Adamec et al.
ACTA NEUROPATHOLOGICA (2002)
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh et al.
NATURE (2002)
Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments
AD Alonso et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia
R Fukuyama et al.
EUROPEAN NEUROLOGY (2001)
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