Molecular mechanisms of antibiotic resistance revisited

Editorial Material Microbiology

Drown Them in Their Own Garbage: a New Strategy To Reverse Polymyxin Resistance?

Kerrie L. May

Summary: Purcell and colleagues have discovered that inactivating a single lipid recycling enzyme leads to the accumulation of waste lipid by-products, which inhibit a key factor responsible for polymyxin resistance.

JOURNAL OF BACTERIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Emergence of methicillin resistance predates the clinical use of antibiotics

Jesper Larsen et al.

Summary: This study reveals that methicillin-resistant Staphylococcus aureus (MRSA) strains were present in European hedgehogs before the discovery of antibiotics and have spread among hedgehog populations and between hedgehogs and secondary hosts. The study also shows that the hedgehog dermatophyte Trichophyton erinacei produces two beta-lactam antibiotics that give an advantage to MRSA strains. These findings emphasize the importance of understanding and managing antibiotic resistance in both wild animals and different ecosystems.

NATURE (2022)

添加到收藏夹

Review Microbiology

Tolerance and resistance of microbial biofilms

Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci

Merianne Mohamad et al.

Summary: The study reveals the importance of Sal proteins as a common source of resistance to pleuromutilin (PLM) in various species of staphylococci. Different Sal-type proteins have varying abilities to mediate resistance to PLMs and other antibiotics, and specific sal genes are intrinsic to particular staphylococcal species. The cryo-EM structure of a representative Sal-type protein in complex with the staphylococcal ribosome shows that Sal proteins bind to the E site and protect the target by displacing PLMs and other antibiotics through an allosteric mechanism.

NUCLEIC ACIDS RESEARCH (2022)

添加到收藏夹

Editorial Material Microbiology

Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors

Krisztina M. Papp-Wallace et al.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Infectious Diseases

High prevalence of colistin resistance and mcr-9/10 genes in Enterobacter spp. in a tertiary hospital over a decade

Weichao Liao et al.

Summary: This study investigated the prevalence of colistin resistance and mcr genes in clinical Enterobacter spp. isolates in a tertiary hospital in China between 2011 and 2020. The results showed a high prevalence of colistin resistance, with a range of 17.1% to 34.5% and an overall prevalence of 22.2%. No mcr-1 to mcr-8 genes were identified in the colistin-resistant Enterobacter spp. isolates, but mcr-9 and mcr-10 were detected at rates of 8.4% and 12.6%, respectively. Most mcr-9/10 genes were located on plasmids, and the plasmid backbones differed between mcr-9 and mcr-10. This study highlights the urgent need to control the prevalence of colistin resistance and prevent the dissemination of mcr-9/10 genes in clinical Enterobacter spp. isolates.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2022)

添加到收藏夹

Review Infectious Diseases

MDR Pumps as Crossroads of Resistance: Antibiotics and Bacteriophages

Pavel A. Nazarov

Summary: Antibiotic resistance is a global problem in modern medicine, and the development of new antibiotics is either expensive or ineffective. Therefore, alternative approaches to bacterial infections, such as phage therapy, are necessary. Bacterial multidrug resistance (MDR) pumps play a key role in antibiotic resistance, while specific defense mechanisms such as drug target modification and inactivation are secondary. Bacteriophages have evolved along with MDR pumps and can enter bacterial cells by binding to them, offering the potential for delaying or preventing the post-antibiotic era.

ANTIBIOTICS-BASEL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks

Arthur Newbury et al.

Summary: The spread of antimicrobial resistance genes in microbial communities is associated with the structure of bacteria-plasmid networks. Mutualistic bacteria-plasmid networks, where antibiotics are present and plasmids carry resistance genes, are more generalized than antagonistic interactions. The fitness benefits of harboring a mutualistic symbiont promote its spread to other species. In addition, coevolution and stability play a role in explaining the link between mutualistic and antagonistic interactions and network structure.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Review Immunology

How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery

Amala Bhagwat et al.

Summary: This article discusses various approaches and strategies to address drug resistance in tuberculosis, including developing new drugs or drug combinations, improving the efficacy of existing drugs, and understanding the importance of resistance mechanisms and cross-resistance.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases

Alexandria B. Purcell et al.

Summary: Gram-negative bacteria modify their surface structures using glycerophospholipids (GPLs) as phosphoform donors, with the key enzyme EptA playing a critical role in antimicrobial resistance by adding pEtN to lipid A. Inhibition of EptA activity during DAG accumulation prevents disruption of GPL synthesis and helps maintain cell envelope homeostasis, affecting antibiotic resistance in Gram-negative bacteria, including resistance to polymyxin.

JOURNAL OF BACTERIOLOGY (2022)

添加到收藏夹

Review Microbiology

Proximate and ultimate causes of the bactericidal action of antibiotics

Fernando Baquero et al.

Summary: While we have a good understanding of the proximate mechanisms of antibiotics, the ultimate mechanisms by which antibiotics kill bacteria remain unclear and subject to further debate and exploration.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

The impact of genetic diversity on gene essentiality within the Escherichia coli species

Francois Rousset et al.

Summary: Bacteria from the same species can vary widely in their gene content, leading to significant differences in gene essentiality between strains and conditions. Genetic determinants for these variations emphasize the importance of epistatic interactions with mobile genetic elements, particularly in triggering the essentiality of persistent genes.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Emily Bordeleau et al.

Summary: Apramycin, an aminoglycoside antibiotic, has a unique structure and resistance mechanism, making it a promising candidate in combating multidrug-resistant pathogens.

MBIO (2021)

添加到收藏夹

Article Microbiology

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

Christopher E. Morgan et al.

Summary: Acinetobacter baumannii, a highly antibiotic-resistant Gram-negative pathogen, utilizes the AdeB multidrug efflux pump to resist a wide range of clinically relevant antimicrobial agents. The study of AdeB pump structures in the presence of ethidium bromide reveals that each AdeB protomer within the trimer can independently recognize and extrude drugs. This sheds light on the drug transport mechanism involving multiple multidrug-binding sites and various transient states of the AdeB membrane protein.

MBIO (2021)

添加到收藏夹

Article Microbiology

Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus

Robert E. Weber et al.

Summary: GWAS identified MprF P314L and L826F mutations as significantly associated with DAP resistance in clinical S. aureus isolates, indicating convergent evolution. Rare genetic variants were also found within mprF and putative candidate genes, while no genetic variants were associated with CPT resistance.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Microbiology

Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

Emily E. Whittle et al.

Summary: Efflux is important for maintaining low intracellular accumulation only in actively growing cells, while envelope permeability is the predominant factor in stationary-phase cells. This study suggests that antibiotics with intracellular targets may be less effective in complex infections with nongrowing or slow-growing bacteria, and efflux inhibitors may potentiate the activity of existing antibiotics in actively growing bacterial infections. The remodeling of the cell envelope prior to stationary phase could provide novel drug targets.

MBIO (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii

Bahare Salehi et al.

Summary: The majority of Acinetobacter baumannii isolates in this study were extensively drug-resistant, with efflux pump activity observed in 40% of isolates against multiple antibiotics, mainly tigecycline. Various amino acid substitutions were detected in the products of regulatory genes, with the G186V mutation in AdeS associated with efflux pump overexpression. No insertion sequences were detected. Further studies are needed to understand the exact role of RND efflux pumps in multidrug-resistant clinical isolates of A. baumannii.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2021)

添加到收藏夹

Review Microbiology

The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges

Mouna Hamel et al.

Summary: This review discusses the history of colistin, the methods used over the decades to discover the main resistance mechanisms, and new technological approaches to explore new target genes. The most advanced technologies such as MALDI-TOF-MS, high throughput sequencing, and genetic toolbox have been highlighted, along with promising new approaches like omics tools and CRISPR-Cas9 and the challenges they face. Despite advancements, colistin resistance mechanisms remain complex.

MICROORGANISMS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Enzymes of the Rifamycin Antibiotic Resistome

Matthew D. Surette et al.

Summary: Rifamycin antibiotics, including rifampin, rifabutin, and rifapentine, are derived from natural rifamycins and primarily used to treat mycobacterial infections such as tuberculosis. These antibiotics inhibit bacterial RNA polymerase by binding to the beta-subunit, leading to cell death. Resistance to rifamycin antibiotics mainly arises from point mutations in RNA polymerase among clinical strains, while environmental mycobacteria and actinomycetes show a richer and diverse rifamycin resistome with various enzymatic mechanisms.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

Ilyas Alav et al.

Summary: Tripartite efflux pumps and related type 1 secretion systems in Gram-negative organisms exhibit diverse functions, energization, and structural organization. This review highlights the role of periplasmic adaptor proteins (PAPs) in providing a common architectural scaffold and proposes a new integrated model of PAP-mediated communication within these systems.

CHEMICAL REVIEWS (2021)

添加到收藏夹

Article Microbiology

Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes

Laura Carrilero et al.

Summary: Plasmids play a crucial role in bacterial evolution by transferring functional genes between lineages, driving genomic diversification. Plasmid coexistence in bacterial genomes is stably maintained through compensatory evolution to reduce fitness costs, unless positive selection for plasmid-borne gene functions is present. Positive selection leads to unstable plasmid coexistence, discriminating between differential fitness benefits of functionally redundant plasmid replicons. This study helps explain the forces structuring bacterial genomes, highlighting the importance of rare positive selection or nonredundancy of accessory gene functions among coexisting plasmids.

MBIO (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bacterial persisters are a stochastically formed subpopulation of low-energy cells

Sylvie Manuse et al.

Summary: Persisters are a small subpopulation of bacterial cells tolerant to antibiotic killing, and their formation is related to low levels of energy-generating enzymes. These low ATP cells are formed stochastically due to fluctuations in the abundance of energy-generating components, suggesting a general low energy mechanism of persister formation.

PLOS BIOLOGY (2021)

添加到收藏夹

Article Biology

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

Akshay Sabnis et al.

Summary: Colistin is a last-resort antibiotic with poor efficacy due to growing resistance. Recent research has shown that colistin exerts bactericidal activity by targeting lipopolysaccharide in the cytoplasmic membrane of bacteria. These findings offer insight into novel approaches for enhancing therapeutic outcomes.

ELIFE (2021)

添加到收藏夹

Article Microbiology

Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria

Silke Huber et al.

Summary: Whole genome sequencing is a useful tool for monitoring resistance mechanisms in bacteria. This retrospective study found that the major resistance mechanisms in linezolid-resistant Staphylococcus epidermidis (LRSE) were mutations in 23S rRNA and the presence of the cfr gene, with most LRSE isolates showing high resistance levels to linezolid. Linezolid usage was identified as the main factor contributing to the development of resistance, and monitoring of the cfr gene in LRSE and restriction of linezolid usage are potential key steps to reduce resistance and transmission.

MICROORGANISMS (2021)

添加到收藏夹

Review Microbiology

Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria

Stefan Schwarz et al.

Summary: Mobile oxazolidinone resistance genes such as cfr, optrA, and poxtA are found on various platforms and may overlap with other resistance genes, contributing to the dissemination of resistance among microbial populations.

CLINICAL MICROBIOLOGY REVIEWS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

Johanna Ude et al.

Summary: This study found that all porins in Pseudomonas aeruginosa were not essential for bacterial growth in rich medium and consumption of diverse hydrophilic nutrients. However, nutrients with multiple carboxylate groups permeated poorly in the absence of porins. Porins provided efficient pathways for nutrient uptake while effectively excluding most antibiotics except carbapenems, with outer-membrane lipid bilayer serving as a major pathway for nutrient and drug entry into the bacterial cell.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Allosteric drug transport mechanism of multidrug transporter AcrB

Heng-Keat Tam et al.

Summary: Gram-negative bacteria maintain intrinsic resistance against noxious compounds through highly efficient efflux pumps. The AcrB drug efflux pump of E. coli, comprising three interdependent protomers, cycles through different states during cooperative catalysis. Structural analysis reveals novel drug-binding sites and transport pathways, suggesting allosteric modulation of drug transport in the presence of multiple drugs.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Caillan Crowe-McAuliffe et al.

Summary: The target protection proteins provide resistance to Gram-positive bacteria by directly binding to the antibiotic target. The research reveals the mechanism by which ABC proteins F-subtype bind to the ribosome to mediate antibiotic release. Understanding these resistance mechanisms is crucial for the future development of antibiotics.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Infectious Diseases

Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time

Martijn Zwama et al.

Summary: The rise in multidrug resistance poses a major threat to human health globally due to the over-expression of multidrug efflux pumps and amino acid substitutions within the pumps themselves causing increased drug efflux efficiency. Studies on clinically, environmentally and laboratory-evolved Gram-negative bacterial strains have shown mutations in the RND-type pumps leading to decreased drug sensitivity. Understanding the evolution and variations in efflux pumps is crucial for the development of novel antibiotics and efflux pump inhibitors.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Review Medicine, General & Internal

A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility

Rita Elias et al.

Summary: Klebsiella pneumoniae is a common nosocomial infection bacteria with increasing multidrug resistance strains. The antibiotic colistin has been gaining attention for its effectiveness against MDR K. pneumoniae strains, but its complex mode of action and various side effects present challenges. Resistance to colistin can occur through alterations in lipid A net charge or plasmid-encoded genes, and the diversity of molecular markers for resistance complicates monitoring methods.

DIAGNOSTICS (2021)

添加到收藏夹

Review Multidisciplinary Sciences

Permeability barriers of Gram-negative pathogens

Helen I. Zgurskaya et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

添加到收藏夹

Review Multidisciplinary Sciences

AcrB: a mean, keen, drug efflux machine

Jessica Kobylka et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

添加到收藏夹

Article Microbiology

Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Liyuan Wang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

Agnieszka Wrobel et al.

JOURNAL OF ANTIBIOTICS (2020)

添加到收藏夹

Article Microbiology

Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-ToIC, Increases Mutation Rate and Influences Drug Resistance Phenotype

Elizabeth M. Grimsey et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The EnteroBase user's guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity

Zhemin Zhou et al.

GENOME RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

TraDIS-Xpress: a high-resolution whole-genome assay identifies novel mechanisms of triclosan action and resistance

Muhammad Yasir et al.

GENOME RESEARCH (2020)

添加到收藏夹

Letter Infectious Diseases

High prevalence of Escherichia coli clinical isolates in India harbouring four amino acid inserts in PBP3 adversely impacting activity of aztreonam/avibactam

Hariharan Periasamy et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB

Heng-Keat Tam et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of vancomycin resistance

Peter J. Stogios et al.

PROTEIN SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Qingan Sun et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Microbiology

Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB

Jiayuan Huang et al.

FUTURE MICROBIOLOGY (2020)

添加到收藏夹

Article Microbiology

Parallel Evolution of Tobramycin Resistance across Species and Environments

Michelle R. Scribner et al.

mBio (2020)

添加到收藏夹

Review Microbiology

(p)ppGpp and Its Role in Bacterial Persistence: New Challenges

Olga Pacios et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging High-Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

Liang-Xing Fang et al.

BIOESSAYS (2020)

添加到收藏夹

Review Infectious Diseases

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

Dalal Hammoudi Halat et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹

Article Biology

Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

Andrew J. Gasparrini et al.

COMMUNICATIONS BIOLOGY (2020)

添加到收藏夹

Review Microbiology

Target protection as a key antibiotic resistance mechanism

Daniel N. Wilson et al.

NATURE REVIEWS MICROBIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment

Dijun Du et al.

STRUCTURE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets

Adam J. Schaenzer et al.

TRENDS IN MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Microbiology

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry

Carmen Gu Liu et al.

MBIO (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates

Andrei Papkou et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Immunology

Aminoglycoside Resistance Updates with a Focus on Acquired 16S Ribosomal RNA Methyltransferases

Jun-Ichi Wachino et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Synthetic group A streptogramin antibiotics that overcome Vat resistance

Qi Li et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

Marie Glavier et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Microbiology

A Novel KPC Variant KPC-55 inKlebsiella pneumoniaeST307 of Reinforced Meropenem-Hydrolyzing Activity

Eun-Jeong Yoon et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹

Review Chemistry, Medicinal

β-lactam antibiotics: An overview from a medicinal chemistry perspective

Lidia Moreira Lima et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance

Natassja G. Bush et al.

MOLECULES (2020)

添加到收藏夹

Article Infectious Diseases

The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance

Anna Elisabeth Ebbensgaard et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹

Review Microbiology

Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges

Ferdinando F. Andrade et al.

MICROORGANISMS (2020)

添加到收藏夹

Article Infectious Diseases

Identification of the novel class D beta-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus

Manuela Tietgen et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

添加到收藏夹

Review Microbiology

Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system

Inseong Jo et al.

JOURNAL OF MICROBIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ribosome protection by ABC-F proteins-Molecular mechanism and potential drug design

Rya Ero et al.

PROTEIN SCIENCE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Catherine L. Tooke et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

添加到收藏夹

Review Microbiology

Definitions and guidelines for research on antibiotic persistence

Nathalie Q. Balaban et al.

NATURE REVIEWS MICROBIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer

Sophie Nolivos et al.

SCIENCE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

Nathanael A. Caveney et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Microbiology

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Tao He et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹

Article Infectious Diseases

Detection of NDM-19, a novel variant of the New Delhi metallo-β-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland

Stefano Mancini et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2019)

添加到收藏夹

Review Microbiology

Bacteria's different ways to recycle their own cell wall

Christoph Mayer et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2019)

添加到收藏夹

Article Infectious Diseases

Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals

Mariana Castanheira et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism

Kenta Tsutsumi et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Microbiology

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli

Jian Sun et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹

Review Microbiology

Transferable Mechanisms of Quinolone Resistance from 1998 Onward

Joaquim Ruiz

CLINICAL MICROBIOLOGY REVIEWS (2019)

添加到收藏夹

Article Microbiology

Conceptual Model of Biofilm Antibiotic Tolerance That Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology

Philip S. Stewart et al.

JOURNAL OF BACTERIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cell Wall Deficiency as a Coping Strategy for Stress

Dennis Claessen et al.

TRENDS IN MICROBIOLOGY (2019)

添加到收藏夹

Article Microbiology

Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?

Shaochun Chen et al.

MBIO (2019)

添加到收藏夹

Article Microbiology

Antibiotics: Combatting Tolerance To Stop Resistance

Etthel M. Windels et al.

MBIO (2019)

添加到收藏夹

Review Microbiology

The evolution and transmission of multi-drug resistant Escherichia coil and Klebsiella pneumoniae: the complexity of clones and plasmids

Steven J. Dunn et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Spatiotemporal dynamics of multidrug resistant bacteria on intensive care unit surfaces

Alaric W. D'Souza et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

Joshua L. C. Wong et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Cell Biology

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

Zeling Xu et al.

CELL REPORTS (2019)

添加到收藏夹

Article Biophysics

Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-ToIC Component AcrA

Zbigniew M. Darzynkiewicz et al.

BIOPHYSICAL JOURNAL (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Deciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance

Ruchika Bhujbalrao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Crystal structure of the multidrug resistance regulator RamR complexed with bile acids

Suguru Yamasaki et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Microbiology

Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

Helen E. McNeil et al.

PLOS PATHOGENS (2019)

添加到收藏夹

Article Microbiology

Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation

Saskia Zimmermann et al.

FRONTIERS IN MICROBIOLOGY (2019)

添加到收藏夹

Review Immunology

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

Atin Sharma et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review

Preeti Pachori et al.

GENES & DISEASES (2019)

添加到收藏夹

Article Microbiology

The hydrophobic trap-the Achilles heel of RND efflux pumps

Zachary Aron et al.

RESEARCH IN MICROBIOLOGY (2018)

添加到收藏夹

Article Infectious Diseases

Diversity of mutations in regulatory genes of resistance-nodulationcell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii

Stefanie Gerson et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

添加到收藏夹

Review Infectious Diseases

Role of bacterial efflux pumps in biofilm formation

Ilyas Alav et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

添加到收藏夹

Review Microbiology

Multidrug efflux pumps: structure, function and regulation

Dijun Du et al.

NATURE REVIEWS MICROBIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

Victoriia Murina et al.

NUCLEIC ACIDS RESEARCH (2018)

添加到收藏夹

Review Genetics & Heredity

Mobile lincosamide resistance genes in staphylococci

Andrea T. Fessler et al.

PLASMID (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Ribosome protection by antibiotic resistance ATP-binding cassette protein

Weixin Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Microbiology

Molecular mechanisms of AcrB-mediated multidrug export

Martijn Zwama et al.

RESEARCH IN MICROBIOLOGY (2018)

添加到收藏夹

Article Microbiology

Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids

Michelle M. C. Buckner et al.

MBIO (2018)

添加到收藏夹

Article Microbiology

An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance

Yongchang Xu et al.

MBIO (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

Martijn Zwama et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The Growing Genetic and Functional Diversity of Extended Spectrum Beta-Lactamases

Sadeeq Ur Rahman et al.

BIOMED RESEARCH INTERNATIONAL (2018)

添加到收藏夹

Review Microbiology

Tetracycline-Inactivating Enzymes

Jana L. Markley et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Article Chemistry, Medicinal

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins

Silvia Acosta-Gutierrez et al.

ACS INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Public, Environmental & Occupational Health

Dissemination of blaNDM-5 gene via an IncX3-type plasmid among non-clonal Escherichia coli in China

Xi Li et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

How Macrolide Antibiotics Work

Nora Vazquez-Laslop et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

添加到收藏夹

Article Microbiology

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae

Crista B. Wadsworth et al.

MBIO (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Genome-wide analysis of horizontally acquired genes in the genus Mycobacterium

Arup Panda et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Microbiology

Look and Outlook on Enzyme-Mediated Macrolide Resistance

Tolou Golkar et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Review Microbiology

The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance

Sakshi Luthra et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation

Imane El Meouche et al.

SCIENCE (2018)

添加到收藏夹

Article Microbiology

The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components

Jonathan W. Handing et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures

Karim Housseini B. Issa et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action

Kalinka Koteva et al.

CELL CHEMICAL BIOLOGY (2018)

添加到收藏夹

Article Genetics & Heredity

A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis

Kristian Alfsnes et al.

MICROBIAL GENOMICS (2018)

添加到收藏夹

Article Infectious Diseases

Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591

Anna Rominski et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-ToIC Multidrug Efflux Pump

Narges Abdali et al.

ACS INFECTIOUS DISEASES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Beta-lactamase database (BLDB) - structure and function

Thierry Naas et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Immunology

Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae

Angela Gomez-Simmonds et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

添加到收藏夹

Review Microbiology

Mechanisms of quinolone action and resistance: where do we stand?

Susana Correia et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Antibiotic tolerance facilitates the evolution of resistance

Irit Levin-Reisman et al.

SCIENCE (2017)

添加到收藏夹

Article Microbiology

ATP-Dependent Persister Formation in Escherichia coli

Yue Shan et al.

MBIO (2017)

添加到收藏夹

Article Multidisciplinary Sciences

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Prateek Sharma et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

Qiue Yang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Cesar A. Lopez et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Microbiology

Extended spectrum beta-lactamase and metallo beta-lactamase production among Escherichia coli and Klebsiella pneumoniae isolated from different clinical samples in a tertiary care hospital in Kathmandu, Nepal

Krishus Nepal et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2017)

添加到收藏夹

Article Biology

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

Zhao Wang et al.

ELIFE (2017)

添加到收藏夹

Article Microbiology

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Diana Machado et al.

FRONTIERS IN MICROBIOLOGY (2017)

添加到收藏夹

Article Infectious Diseases

First report of NDM-1-producing Klebsiella pneumoniae imported from Africa to Italy: Evidence of the need for continuous surveillance

Luigi Principe et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

The secondary resistome of multidrug-resistant Klebsiella pneumoniae

Bimal Jana et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Infectious Diseases

Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli

Sushovan Dam et al.

ANTIBIOTICS-BASEL (2017)

添加到收藏夹

Review Microbiology

Structure, function and regulation of Pseudomonas aeruginosa porins

Sylvie Chevalier et al.

FEMS MICROBIOLOGY REVIEWS (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications

Jaroslav Spizek et al.

BIOCHEMICAL PHARMACOLOGY (2017)

添加到收藏夹

Review Infectious Diseases

Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy

Caroline M. Pule et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria

Yinhu Wang et al.

CURRENT DRUG TARGETS (2016)

添加到收藏夹

Article Immunology

Aminoglycoside Resistance The Emergence of Acquired 16S Ribosomal RNA Methyltransferases

Yohei Doi et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2016)

添加到收藏夹

Article Infectious Diseases

Inactivation or inhibition of AcrAB-TolC increases resistance of carbapenemase-producing Enterobacteriaceae to carbapenems

Howard T. H. Saw et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

添加到收藏夹

Article Infectious Diseases

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

Yi-Yun Liu et al.

LANCET INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Microbiology

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

Liam K. R. Sharkey et al.

MBIO (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Rifampin phosphotransferase is an unusual antibiotic resistance kinase

Peter J. Stogios et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

Christine Oswald et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance

Stefan Schwarz et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Approved Glycopeptide Antibacterial Drugs: Mechanism of Action and Resistance

Daina Zeng et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

Dilay Hazel Ayhan et al.

PLOS BIOLOGY (2016)

添加到收藏夹

Article Biology

Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

Jean-Emmanuel Hugonnet et al.

ELIFE (2016)

添加到收藏夹

Article Microbiology

Carbapenem Resistance in Acinetobacter baumannii and Other Acinetobacter spp. Causing Neonatal Sepsis: Focus on NDM-1 and Its Linkage to ISAba125

Somdatta Chatterjee et al.

FRONTIERS IN MICROBIOLOGY (2016)

添加到收藏夹

Article Infectious Diseases

Mechanisms of drug resistance: daptomycin resistance

Truc T. Tran et al.

ANTIMICROBIAL THERAPEUTICS REVIEWS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes

Kevin J. Forsberg et al.

CHEMISTRY & BIOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode

Jin-Sik Kim et al.

MOLECULES AND CELLS (2015)

添加到收藏夹

Article Microbiology

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

Henrietta Venter et al.

FRONTIERS IN MICROBIOLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

Leo Lin et al.

EBIOMEDICINE (2015)

添加到收藏夹

Review Microbiology

Molecular mechanisms of antibiotic resistance

Jessica M. A. Blair et al.

NATURE REVIEWS MICROBIOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Genetic Basis and Functional Consequences of Differential Expression of the CmeABC Efflux Pump in Campylobacter jejuni Isolates

Tara Grinnage-Pulley et al.

PLOS ONE (2015)

添加到收藏夹

Article Microbiology

First Report of NDM-1-Producing Acinetobacter baumannii Sequence Type 25 in Brazil

Marcelo Pillonetto et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

添加到收藏夹

Article Microbiology

Rapid Conversion of Pseudomonas aeruginosa to a Spherical Cell Morphotype Facilitates Tolerance to Carbapenems and Penicillins but Increases Susceptibility to Antimicrobial Peptides

Leigh G. Monahan et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

添加到收藏夹

Review Infectious Diseases

Mechanisms of antibiotic resistance in enterococci

William R. Miller et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2014)

添加到收藏夹

Review Medicine, Research & Experimental

Mechanisms of vancomycin resistance in Staphylococcus aureus

Susana Gardete et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the AcrAB-TolC multidrug efflux pump

Dijun Du et al.

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria

Peter Spanogiannopoulos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Porter domain opening and closing motions in the multi-drug efflux transporter AcrB

Nadine Fischer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

添加到收藏夹

Article Infectious Diseases

Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli

Marlen Adler et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)

添加到收藏夹

Review Microbiology

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Alan P. Johnson et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2013)

添加到收藏夹

Letter Medicine, General & Internal

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Jose Melo-Cristino et al.

LANCET (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis

Jonathan Gisin et al.

NATURE CHEMICAL BIOLOGY (2013)

添加到收藏夹

Article Microbiology

Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes

Peter Spanogiannopoulos et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

添加到收藏夹

Review Microbiology

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

Lucia Fernandez et al.

CLINICAL MICROBIOLOGY REVIEWS (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Daptomycin Resistance in Enterococci Is Associated with Distinct Alterations of Cell Membrane Phospholipid Content

Nagendra N. Mishra et al.

PLOS ONE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

Georgina Cox et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

Errett C. Hobbs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Substrate Specificity within a Family of Outer Membrane Carboxylate Channels

Elif Eren et al.

PLOS BIOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-ToIC

Elena B. Tikhonova et al.

CHEMISTRY & BIOLOGY (2011)

添加到收藏夹

Review Microbiology

Plasmids in Gram negatives: Molecular typing of resistance plasmids

Alessandra Carattoli

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Ryosuke Nakashima et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Altered Antibiotic Transport in OmpC Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. coli

Hubing Lou et al.

PLOS ONE (2011)

添加到收藏夹

Review Microbiology

Updated Functional Classification of beta-Lactamases

Karen Bush et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

添加到收藏夹

Article Microbiology

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

Jennifer H. Moffatt et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions

Gianfranco De Pascale et al.

CHEMBIOCHEM (2010)

添加到收藏夹

Review Microbiology

Alarming beta-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

Karen Bush

CURRENT OPINION IN MICROBIOLOGY (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Aminoglycoside modifying enzymes

Maria S. Ramirez et al.

DRUG RESISTANCE UPDATES (2010)

添加到收藏夹

Review Public, Environmental & Occupational Health

Does microbial resistance or adaptation to biocides create a hazard in infection prevention and control?

B. Meyer et al.

JOURNAL OF HOSPITAL INFECTION (2010)

添加到收藏夹

Article Microbiology

Characterization of a New Metallo-beta-Lactamase Gene, bla(NDM-1), and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

Dongeun Yong et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

添加到收藏夹

Article Immunology

Vancomycin-resistant staphylococcus aureus in the United States, 2002-2006

Dawn M. Sievert et al.

CLINICAL INFECTIOUS DISEASES (2008)

添加到收藏夹

Review Microbiology

Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes

Marilyn C. Roberts

FEMS MICROBIOLOGY LETTERS (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism

T. Jaeger et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

添加到收藏夹

Review Microbiology

Penicillin-binding proteins and beta-lactam resistance

Andre Zapun et al.

FEMS MICROBIOLOGY REVIEWS (2008)

添加到收藏夹

Review Pharmacology & Pharmacy

Synthetic lipopeptides: a novel class of anti-infectives

Roman Jerala

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)

添加到收藏夹

Review Microbiology

Carbapenemases:: the versatile β-lactamases

Anne Marie Queenan et al.

CLINICAL MICROBIOLOGY REVIEWS (2007)

添加到收藏夹

Article Microbiology

A new evolutionary variant of the streptogramin A resistance protein, vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides

G. Novotna et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystal structure of osmoporin OmpC from E-coli at 2.0 Å

Arnaud Basle et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

添加到收藏夹

Article Microbiology

The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptograrnin A antibiotics

Katherine S. Long et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

添加到收藏夹

Article Infectious Diseases

Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii

C Héritier et al.

CLINICAL MICROBIOLOGY AND INFECTION (2006)

添加到收藏夹

Article Microbiology

Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC

V Ricci et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

添加到收藏夹

Review Microbiology

The bacterial ribosome as a target for antibiotics

J Poehlsgaard et al.

NATURE REVIEWS MICROBIOLOGY (2005)

添加到收藏夹

Review Pharmacology & Pharmacy

Bacterial resistance to antibiotics: Modified target sites

PA Lambert

ADVANCED DRUG DELIVERY REVIEWS (2005)

添加到收藏夹

Review Pharmacology & Pharmacy

Bacterial resistance to antibiotics: Enzymatic degradation and modification

GD Wright

ADVANCED DRUG DELIVERY REVIEWS (2005)

添加到收藏夹

Review Chemistry, Multidisciplinary

Rifamycin-mode of action, resistance, and biosynthesis

HG Floss et al.

CHEMICAL REVIEWS (2005)

添加到收藏夹

Article Microbiology

MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli

S Chen et al.

JOURNAL OF BACTERIOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC

MK Higgins et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Broad-spectrum peptide inhibitors of aminoglycoside antibotic resistance enzymes

DD Boehr et al.

CHEMISTRY & BIOLOGY (2003)

添加到收藏夹

Article Infectious Diseases

The importance of efflux pumps in bacterial antibiotic resistance

MA Webber et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)

添加到收藏夹

Review Microbiology

Molecular basis of bacterial outer membrane permeability revisited

H Nikaido

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Crystal structure of bacterial multidrug efflux transporter AcrB

S Murakami et al.

NATURE (2002)

添加到收藏夹

Article Microbiology

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae

WL Veal et al.

JOURNAL OF BACTERIOLOGY (2002)

添加到收藏夹

Review Biochemistry & Molecular Biology

The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery

A Bermingham et al.

BIOESSAYS (2002)

添加到收藏夹

Review Biochemistry & Molecular Biology

MicF:: An antisense RNA gene involved in response of Escherichia coli to global stress factors

N Delihas et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

添加到收藏夹

Review Pharmacology & Pharmacy

Sulfonamide resistance: mechanisms and trends

O Skold

DRUG RESISTANCE UPDATES (2000)

添加到收藏夹

Molecular mechanisms of antibiotic resistance revisited

相关参考文献