Chromatin oxygen sensing by histone H3 prolyl hydroxylation

A new study identifies prolyl hydroxylation of histone H3 as a signal for the recruitment of KDM5A, altering H3K4me3 and gene expression. H3P16oh is independent of the HIF hypoxia-sensing pathway and provides a further layer of complexity to oxygen-sensitive chromatin modifications.

Automated summary

A new study reveals that prolyl hydroxylation of histone H3 serves as a signal for the recruitment of KDM5A, leading to changes in H3K4me3 and gene expression. This hydroxylation is independent of the HIF hypoxia-sensing pathway and adds another layer of complexity to oxygen-sensitive chromatin modifications.