期刊
NATURE CHEMICAL BIOLOGY
卷 18, 期 12, 页码 1330-1340出版社
NATURE PORTFOLIO
DOI: 10.1038/s41589-022-01203-3
关键词
-
资金
- National Key Research and Development Program of China [2020YFA0907702, 2021YFA0909502]
- National Natural Science Foundation of China [32071414, 32270107, 22075179]
- Natural Science Foundation of Shanghai [21ZR1432100]
This article reviews the unique properties of protein condensates and discusses the prospects and challenges of utilizing them for targeted design and manipulation of biological functions. Recent advances in mining protein components and engineering approaches for creating and manipulating designer condensates are highlighted. These advances will have significant impacts on synthetic biology.
Protein condensates are distinct structures assembled in living cells that concentrate molecules via phase separation in a confined subcellular compartment. In the past decade, remarkable advances have been made to discover the fundamental roles of the condensates in spatiotemporal control of cellular metabolism and physiology and to reveal the molecular principles, components and driving forces that underlie their formation. Here we review the unique properties of the condensates, the promise and hurdles for harnessing them toward purposeful design and manipulation of biological functions in living cells. In particular, we highlight recent advances in mining and understanding the proteinaceous components for creating designer condensates, along with the engineering approaches to manipulate their material properties and biological functions. With these advances, a greater variety of complex organelle-like structures can be built for diverse applications, with unprecedented effects on synthetic biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据