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START smuggling CoQ to fight ferroptosis

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NATURE CELL BIOLOGY
卷 -, 期 -, 页码 -

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NATURE PORTFOLIO
DOI: 10.1038/s41556-022-01044-1

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A study suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ from mitochondria to the plasma membrane.
Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.

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