4.4 Article

Characterization of metabolites of sagittatoside B in rats using UPLC-QTOF-MS spectrometry

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NATURAL PRODUCT RESEARCH
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TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2023.2172006

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Sagittatoside B; metabolites; metabolic pathways; UPLC; Q-TOF-MS

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In this study, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was used to analyze the metabolites of Sagittatoside B in rats. A total of 17 metabolites were detected or tentatively identified from rat plasma, bile, urine, and feces. The major metabolic pathways of Sagittatoside B in rats involved hydrolysis, hydrogenation, hydroxylation, dehydrogenation, demethylation, decarbonylation, and conjugation with glucuronic acid and different sugars. This research provides valuable insights into the metabolism of Sagittatoside B and serves as a reference for the metabolism of active flavonoid compounds.
Sagittatoside B is one of the principal diglucosides in Herba Epimedii. In this work, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was applied to the rapid analysis of sagittatoside B metabolites in rats after oral administration. A total number of 17 metabolites were detected or tentatively identified from rat plasma, bile, urine and feces. The major metabolic pathways of sagittatoside B in rats were hydrolysis, hydrogenation, hydroxylation, dehydrogenation, demethylation, decarbonylation and conjugation with glucuronic acid and different sugars. This work revealed the metabolism of sagittatoside B in vivo, and reported the characteristic metabolic reactions of sagittatoside B for the first time. This provided the basis for the further research and development of sagittatoside B, and also provided reference for the metabolism of active flavonoid compounds.

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