4.4 Article

Antiproliferative ent-abietane diterpenoids from Euphorbia fischeriana

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NATURAL PRODUCT RESEARCH
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TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2023.2169686

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Euphorbia fischeriana; ent-abietane; structure elucidation; biological activity; anti-proliferative

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Two previously undescribed ent-abietane diterpenoids, Euphorfinoids M and N, along with seven known analogues, were isolated from the roots of wild Euphorbia fischeriana. Their structures were determined by spectroscopic analysis and comparison with structurally related known analogues. Compound 1 exhibited the highest activity with an IC50 value of 3.62 +/- 0.31 mu M against the proliferative effects of HeLa cell line.
Euphorfinoids M and N (1 and 2), two previously undescribed ent-abietane diterpenoids, together with seven known analogues (3-9), were isolated from the roots of wild Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, ECD, and comparison with structurally related known analogues. Bioassays against proliferative effects of HeLa cell line showed that compound 1 was the most active with IC50 3.62 +/- 0.31 mu M.

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